Sayan Gupta, Ph.D.
National Synchrotron Light Source
Bldg. 725A-X28C
Brookhaven National Laboratory
Upton, NY 11973
Office Location: Bldg. 535A-M4
Phone: (631) 344-3725
Fax: (631) 344-5496
Email: sayan@bnl.gov
Faculty Appointments
Case Center for Proteomics (Instructor)
Center for Synchrotron Biosciences at NSLS, BNL
Academic History
| 2001 | Ph.D., Biophysics and Biochemistry, Tata Institute of Fundamental Research, Mumbai, India |
Positions and Employment
| 1996-2001 | Research Scholar, Department of Chemical Sciences, Tata Institute of Fundamental Research: A National Center of Nuclear Sciences and Mathematics, Department of Atomic Energy, Govt. of India, Mumbai. |
| 2002-2005 | Research Associate, Department of Physiology and Biophysics, Albert Einstein College of Medicine, Yeshiva University, NY. |
| 2002- | Beamline Scientist, Center for Synchrotron Biosciences, National Synchrotron Light Source, Brookhaven National Laboratory, NY |
| 2005- | Instructor, Center for Proteomics, Case Western Reserve University |
Research
My research is focused on Synchrotron Protein Footprinting to investigate the structure and dynamics of biological macromolecule and their complexes in solution. Synchrotron Footprinting have been successfully used to study enzyme cofactor interaction, protein-protein interactions and protein nucleic interactions. Currently we are investigating structure of large biomolecular assemblies and developing methodologies for the study of membrane bound receptor. Our research is also focus on the study of protein-protein and protein-nucleic interactions in living cell. We are developing beamline optics and instrumentation for efficient protein x-ray radiolysis and faster time resolve techniques to study ultra-fast biological processes in the synchrotron light source, and improving mass spectrometric methodologies for quantitative analysis.
Web Links
http://www.nsls.bnl.gov/
http://www.lightsources.org/cms/
http://www.tifr.res.in/
Recent Publications
- Gupta, S., Warne, A., Saraste, M., Mazumdar, S. pH-induced Conformational Transition in the Soluble CuA Domain of Paracoccus denitrificans Cytochrome Oxidase. Biochemistry (2001), 40, 6180-6189.
- Das, N., Gupta, S., Mazumdar, S. Direct Observation of Cytochrome c from Lipid-Encapsulated Protein by Peroxide and Superoxide: A Possible Mechanism for Drug Induced Apoptosis. Biochemical and Biophysical Research Communication (2001), 286, 311-314.
- Gupta, S., Mangel, W.F., McGrath, W.J., Perek, J.L., Lee, D.W., Takamoto, K.G., Chance, M.R. DNA binding provides a molecular strap activating the Adenovirus Proteinase. Molecular and Cellular Proteomics (2004), 3, 950-959.(cover article)
- Shcherbakova, I., Gupta, S., Chance, M.R., Brenowitz, M. Monovalent ion-mediated folding of the Tetrahymena thermophila ribozyme. Jounrnal of Molecular Biology (2004), 342, 1431-1442.
- Gupta, S., Mangel, F.W., Sullivan, M., Takamoto, K., Chance, M.R. Mapping a Functional Viral Protein in Solution Using Synchrotron X-ray Footprinting Technology. Synchrotron Radiation News, (2005), 18(1):25-34.(cover article)
- Marinkovic, N.S., Gupta, S., Zhan, C., Chance, M.R. Synchrotron Radiation in Biosciences. Nuclear Instruments and Methods in Physics Research B, (2005), 241, 242-246.