|
|
PREVENTION – WOMENS' CARDIOVASCULAR
HEALTH
Research
HERS: Heart and Estrogen/Progestin Replacement
Study
This
was a randomized, blinded placebo-controlled trial involving 2763
post-menopausal women who were randomized to an estrogen/progestin
combination or placebo. This study demonstrated that combination hormone
therapy in subjects with heart disease did not prevent further heart attacks
or death from CHD. There was, however, an increase in thrombotic
complications, such as DVT and PE. The therapy was associated with positive
effects on lipoproteins, with a lowering of LDL-cholesterol and increase in
HDL-cholesterol.
|
|