CEREBRAL ANEURYSMS
Types of Aneurysms, Etiologies and Risk Factors
Risk Factors1,2,5:
Any conditions which either compromise the integrity of the vasculature, increase pressure in vessels, or contribute to abnormal hemodynamic flow may contribute to aneurysm formation.
Furthermore, studies have found that cigarette smoking, female sex, and younger age have been shown to correlate with aneurysm growth and rupture2.
Conditions associated with high intravascular pressure1,2,5:
Cigarette smoking
Heavy alcohol use
Hypertension
Cocaine
Coarctation of the aorta
Polycystic kidney disease
High flow AVMs
Conditions associated with compromised vascular integrity1,2,5:
Ehlers-Danlos
Marfans
Pseudoxanthoma elasticum
SLE
Takyasu arteritis
Fibromuscular dysplasia
Moyamoya
Osler-Weber-Rendu
Infective processes, particularly bacterial endocarditis
Malignancy
Atherosclerotic changes
Smoking
Trauma
Conditions associated with abnormal hemodynamic flow1,2,5:
Atherosclerotic changes
Abnormal vasculature:
AVM
Osler-Weber-Rendu
In addition, some studies have found that family history of aneurysms, even in the absence of genetic syndromes usually associated with aneurysms, confers a 2-7 fold increased risk of developing at least one aneurysm6.
So called Familial intracranial aneurysm syndrome is diagnosed when 2 or more third degree or closer relatives have been diagnosed with cerebral aneurysms1.
|