Alex Huang, MD, PhD

Contact Information

Wolstein Research Building Room 6528
2103 Cornell Road
Cleveland, OH 44106-7288
Phone: 216-368-1271
Fax: 216-368-0741



Alex Huang, MD, PhD

Associate Professor
Case Western Reserve University School of Medicine
Director, Pediatric Hematology-Oncology Fellowship Program
University Hospitals Case Medical Center / Rainbow Babies & Children’s Hospital

  • Division: Hematology / Oncology


Dr. Huang received a B.S. in chemistry and an M.S. in biochemistry and molecular biology from the University of Chicago. He then entered the medical scientist training program (MSTP) at the Johns Hopkins University School of Medicine where he completed his Ph.D. thesis in the laboratory of Drew M. Pardoll, M.D., Ph.D. Dr. Huang’s Ph.D. thesis included studying the process of in vivo tumor-antigen cross-presentation by bone marrow derived professional antigen presenting cells and identified the dominant MHC class-I restricted tumor rejection antigen, AH-1, in a murine colon tumor model.

After completing pediatric residency at Johns Hopkins Hospital, Dr. Huang entered the combined pediatric hematology/oncology clinical fellowship training program at Johns Hopkins Hospital and the National Cancer Institute. While a postdoctoral fellow in the laboratory of Dr. Ronald N. Germain in the Laboratory of Immunology at NIAID, Dr. Huang received the Cancer Research Institute Postdoctoral Fellowship Award and was among the first to develop the new technique of intravital 2-photon laser scanning microscopy to study immune cell migration and interaction in secondary lymphoid organs and the gastrointestinal track in vivo. In 2006, Dr. Huang joined the Case Western Reserve University School of Medicine faculty as an Assistant Professor in the Division of Pediatric Hematology / Oncology at Rainbow Babies & Children’s Hospital - Rainbow / Seidman Cancer Center with a secondary faculty appointment in the Department of Pathology, Biomedical Engineering and General Medical Sciences, as well as a member of the Case Comprehensive Cancer Center. Currently. Dr. Huang is also the director of clinical fellowship program in Pediatric Hematology / Oncology since 2007. Dr. Huang was promoted to Associate Professor in 2012. Dr. Huang’s laboratory research program is focused on adapting intravital 2-photon laser scanning microscopy to study various aspects of in vivo immunity and pathogenesis. These efforts include investigating the role of tumor and tissue microenvironment in immune cell recruitment and tolerance induction, interplay between inflammation and carcinogenesis, regulation of lymphocyte homeostasis and chemokine receptor control, immune surveillance, and mechanisms of pathogenic immune cell recruitment during autoimmunity and tissue trauma.