Khalequz Zaman, PhD

Contact Information

10900 Euclid Ave, BRB 829
Cleveland, OH 44106
Phone: 216-368-1637
Fax: 216-368-4223

Khalequz.zaman@case.edu

 

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Khalequz Zaman, PhD

Assistant Professor

  • Division: Pulmonology, Allergy and Immunology

Bio

Khalequz Zaman received his B.Sc. and M.S. from the Marie Curie University in Lublin, Poland and he attended at the Jagiellonian University in Krakow, Poland where he was awarded his Ph.D. Dr. Zaman joined to the Division of Pediatric Pulmonology, Department of Pediatric, and Case Western Reserve University School of Medicine in 2013.

Research Interests

One of the main goals of his research projects is to establish the S-nitrosylation signaling in Cystic fibrosis (CF). S-nitrosothiols (SNOs) are endogenous bronchodilators and cell signaling molecules which are normally present in the lungs and tend to be low concentrations in the CF airway. SNOs inhibit the ubiquitin proteasome pathway, stabilizing the expression of post-translational degradation-regulated proteins. As a result there is interest in these compounds as a novel class of corrector therapies for CF. For the last fourteen years, he has focused the exciting area concerning how different SNO sup-regulate the expression, maturation and function of cystic fibrosis (CF) transmembrane conductance regulator (CFTR) in cystic fibrosis airway epithelial cells. The primary goal of his research is to define the novel molecular mechanisms by which SNOs permit CFTR maturation and trafficking to cell surface of airway epithelial cells. These mechanistic insights will allow SNO compounds to be optimized agents for CF therapy.

His group has also established a cell culture core and Dr. Zaman is responsible for the operation of the cell core facility. Overall, cell culture provide primary human airway pseudostratified columnar epithelium grown at air liquid interface from normal subjects and from subjects with CF. In addition, it provides primary human and mice primary endothelial cells and primary adrenal medulla cells. Further, the cell core also maintain active cultures of many types of epithelial cell lines as well as maintain frozen stocks of a large cell library.