Mitchell Drumm, PhD

Contact Information

10900 Euclid Ave, BRB 733

Cleveland, OH 44106

Phone: 216-368-6893

Fax:  216-368-4223




Mitchell L Drumm, PhD


  • Division: Pulmonology, Allergy and Immunology


Mitchell Drumm received his B.S. in genetics from The Ohio State University in 1983 and his Ph.D. in Human Genetics from the University of Michigan in 1990. His doctoral degree work was carried out in the laboratory of Francis Collins, M.D., Ph.D., with whom he was a co-discoverer of the gene that causes cystic fibrosis (CF). Dr. Drumm continues to work on CF and joined the faculty at Case Western Reserve University in 1992 and is a Professor in the Departments of Pediatrics and Genetics and Genome Sciences.

Dr. Drumm’s early work showed that CF cells could be corrected by introduction of a normal copy of the CF gene and laid the groundwork for studies in CF gene therapy. He also demonstrated that the most common mutation found in CF could be manipulated to exhibit channel activity and is credited with initiating the search for drugs that can correct the basic defect in CF. He has authored over 80 peer-reviewed manuscripts and several book chapters on cystic fibrosis and holds three patents relevant to the disease as well.

Current research in the Drumm laboratory focuses on understanding how variants in the genome influence the course of disease for CF patients and how the CF genome adapts to the disease. Understanding these processes so that they may be manipulated for therapy is driving force behind these interests. Through cell and mouse models they have created the lab continues to make novel observations about how the CF lungs work, but also regarding metabolism and growth.

In 2007, Dr. Drumm was appointed Director of Basic Research of the Willard A. Bernbaum Cystic Fibrosis Research Center and in 2011 Vice Chair for Research in the Department of Pediatrics. His research program continues to focus on the genetics of CF, but he also invokes mouse genetics to better understand the disease. Dr. Drumm also serves as an advisor to several cystic fibrosis research centers, reviews grants applications for the National Institutes of Health and co-chairs the Research and Research Training Committee of the Cystic Fibrosis Foundation.

In 2015, Dr. Drumm became the inaugural recipient of the Connie and Jim Brown Professorship in Cystic Fibrosis Research.

In addition to his research program, Dr. Drumm also focuses on education. He directs a summer internship program through the Department of Pediatrics that provides laboratory experience to undergraduates from around the country, mentors undergraduate and graduate students in his lab as well as carry out didactic teaching in the Medical School. Dr. Drumm was awarded the Bruce M. Jackson award for undergraduate mentoring in 2009 for his work with CWRU undergraduates.