Calvin Cotton

Contact Information

10900 Euclid Ave, BRB 825

Cleveland, OH 44106

Phone: 216-368-4603

Fax: 216-844-4223

cuc@case.edu

 

Links

Calvin Cotton, PhD

Associate Professor

  • Division: Pulmonology, Allergy and Immunology

Bio

Dr. Cotton graduated from Duke University with a BS degree in Zoology in 1977. He spent the following year at National Institute of Environmental Health Sciences and Mount Desert Island Biological Laboratory working with Dr. John Pritchard. He completed his graduate training at the University of North Carolina in the laboratories of Drs. John Gatzy and Richard Boucher and received his PhD in 1984. Dr. Cotton undertook postdoctoral training in the laboratory of Dr. Luis Reuss, Department of Physiology, Washington University and Department of Physiology and Biophysics, University of Texas Medical Branch. Dr. Cotton joined the faculty of the Departments of Pediatrics and Physiology and Biophysics at Case Western Reserve University in 1990.

Research Interests
The overall goal of our research is to develop an understanding the cell physiology of transepithelial salt and water transport and the regulation of these processes in health and disease. We are interested in both acute and chronic regulation of electrolyte transport by a variety of signal transduction pathways including those controlled by growth factors and hormones. Our studies currently involve two genetic disorders, cystic fibrosis (CF) and polycystic kidney disease (PKD), characterized by derangements in cell signaling and alterations epithelial ion transport. We utilize multiple types of biological preparations for our studies including: animals, tissue slices, primary cell cultures, immortalized cell lines, and transfected cells. Recently, we have taken advantage of a transgenic mouse that carries a temperature sensitive immortalizing gene to generate conditionally immortalized epithelial cell lines from relevant tissues of normal, PKD and CF mice. The resultant cell lines provide good model systems for exploring normal epithelial cell physiology and for examining the cellular mechanisms of pathophysiology associated with PKD and CF. Other transgenic mouse lines with tissue specific expression of green fluorescent protein or Cre are used to isolate pure populations of cells and to generate tissue specific knockouts of important molecules. Our laboratory is equipped to perform biochemical and molecular studies as well a functional evaluation of ion and water transport.