Qing Yin Zheng, M.D.

Associate Professor
Email: qyz@case.edu
Phone: 216.844.3441

Dr. Qing Yin Zheng is an associate professor in the Department of Otolaryngology- Head and Neck Surgery, University Hospitals of Cleveland, Case Western Reserve University. He earned his Medical Degree at the Binzhou Medical College, his MS in Physiology at Xi’an Medical University. He completed his residency in Neurology in Capital University of Medical Sciences. He was a post doctoral fellow at The Jackson Laboratory (TJL), Bar Harbor, ME. Later, he was promoted to the position of a Research Scientist at TJL. He joined Case in 2006.

The research in Dr. Zheng’s laboratory focuses on a number of areas in genetics, genomics and proteomics of ear diseases in mice and human. Although the human and mouse genomes have been sequenced, much still remains to be understood about how genes are regulated. Dr. Zheng has established a methodology combining genomics and proteomics to study gene expression in mouse inner ears. He and his colleagues have developed a novel SSUMM approach (Subtractive Strategy Using Mouse Mutants, Zheng et al., Brain Research, 2006). SSUMM takes advantage of the differences between control and affected or mutant samples. He proves that SSUMM is a useful method in proteomics, especially in those cases in which the investigator must work with small numbers of diverse cell types from a tiny organ. The overall aim of these studies is to discover genes and molecular pathways that are involved in disease processes in mouse models of human deafness. Otitis media (OM), an inflammation of the middle ear, accounts for over 22 million visits to physicians in the U.S. every year. Mouse models of OM represent powerful tools for advancing the understanding of OM (Zheng et al., Brain Research, 2006). Dr. Zheng’s lab is interested in identifying novel genes and/or novel functions of known genes that underlie OM susceptibility using a functional genomics and phenotype driven approach. These genetic mouse models may be used to develop innovative treatment strategies for human OM. Usher syndrome is the most common condition that involves both hearing and vision problems. Mouse models make it easier to determine the function of the various genes involved in the disease. Understanding the functions of the genes that cause Usher syndrome will lead to improved genetic counseling and early diagnosis, and may eventually expand treatment options. Dr. Zheng and colleagues reported his discovery that interaction of two Usher syndrome genes causes a new type of later-onset hearing impairment both in humans and mice (Zheng et al., Hum Mol Genet, 2005). Based on the findings from his mouse experiments, a digenic inheritance of the USH1 phenotype in three unrelated families with mutations in CDH23 and PCDH15 was also discovered, thus proving the power of mouse genetics to help understand human genetic problems.

Dr. Zheng's current research group


1: Melki SJ, Li Y, Semaan MT, Zheng QY, Megerian CA, Alagramam KN. A Mouse Model Validates the Utility of Electrocochleography in Verifying Endolymphatic Hydrops. J Assoc Res Otolaryngol. 2014 Feb 8. [Epub ahead of print] PubMed PMID: 24509791.

2: Zhang Y, Xu M, Zhang J, Zeng L, Wang Y, Zheng QY. Risk factors for chronic and recurrent otitis media-a meta-analysis. PLoS One. 2014 Jan 23;9(1):e86397. doi: 10.1371/journal.pone.0086397. PubMed PMID: 24466073; PMC3900534.

3: Zhu P, Lin Y, Lin H, Xu Y, Zheng Q, Han Y. Computational fluid dynamics analysis of salivary flow and its effect on sialolithogenesis. Oral Dis. 2013 Sep 12. doi: 10.1111/odi.12182. [Epub ahead of print] PubMed PMID: 24164693.

4: Han F, Yu H, Zheng T, Ma X, Zhao X, Li P, Le L, Su Y, Zheng QY. Otoprotective effects of erythropoietin on Cdh23erl/erl mice.Neuroscience. 2013 May 1;237:1-6. doi: 10.1016/j.neuroscience.2013.01.052. Epub 2013 Feb 4. PubMed PMID: 23384607; PMC3627390.

5: Semaan MT, Zheng QY, Han F, Zheng Y, Yu H, Heaphy JC, Megerian CA. Characterization of neuronal cell death in the spiral ganglia of a mouse model of endolymphatic hydrops. Otol Neurotol. 2013 Apr;34(3):559-69. doi: 10.1097/MAO.0b013e3182868312. PubMed PMID: 23462289; PMC3628741.

6: Zhang YX, Yue Z, Wang PY, Li YJ, Xin JX, Pang M, Zheng QY, Xie SY. Cisplatin upregulates MSH2 expression by reducing miR-21 to inhibit A549 cell growth. Biomed Pharmacother. 2013 Mar;67(2):97-102. doi: 10.1016/j.biopha.2012.11.008. Epub 2012 Dec 28. PubMed PMID: 23485110; PMC3646586.

7: Sheykholeslami K, Thimmappa V, Nava C, Bai X, Yu H, Zheng T, Zhang Z, Li SL, Liu S, Zheng QY. A new mutation of the Atoh1 gene in mice with normal life span allows analysis of inner ear and cerebellar phenotype in aging. PLoS One. 2013;8(11):e79791. doi: 10.1371/journal.pone.0079791. PubMed PMID: 24265785; PMC3827170.

8: Zong L, Lu C, Zhao Y, Li Q, Han D, Yang W, Shen Y, Zheng Q, Wang Q. Clue to a new deafness gene: a large Chinese nonsyndromic hearing loss family linked to DFNA4. J Genet Genomics. 2012 Dec 20;39(12):653-7. doi: 10.1016/j.jgg.2012.11.002. Epub 2012 Nov 16. PubMed PMID: 23273769; PMC3685490.

9: Zhang Y, Yu H, Xu M, Han F, Tian C, Kim S, Fredman E, Zhang J, Benedict-Alderfer C, Zheng QY. Pathological features in the LmnaDhe/+ mutant mouse provide a novel model of human otitis media and laminopathies. Am J Pathol. 2012 Sep;181(3):761-74. doi:

10.1016/j.ajpath.2012.05.031. Epub 2012 Jul 20. PubMed PMID: 22819531; PMC3432432. 10: Zheng QY, Scarborough JD, Zheng Y, Yu H, Choi D, Gillespie PG. Digenic inheritance of deafness caused by 8J allele of myosin-VIIA and mutations in other Usher I genes. Hum Mol Genet. 2012 Jun 1;21(11):2588-98. doi: 10.1093/hmg/dds084. Epub 2012 Feb 29. PubMed PMID: 22381527; PMC3349429.

11: Liu S, Li S, Zhu H, Cheng S, Zheng QY. A mutation in the cdh23 gene causes age-related hearing loss in Cdh23(nmf308/nmf308) mice.Gene. 2012 May 15;499(2):309-17. doi: 10.1016/j.gene.2012.01.084. Epub 2012 Feb 4. PubMed PMID: 22326520; PMC3526976.

12: Han F, Yu H, Tian C, Chen HE, Benedict-Alderfer C, Zheng Y, Wang Q, Han X, Zheng QY. A new mouse mutant of the Cdh23 gene with early-onset hearing loss facilitates evaluation of otoprotection drugs. Pharmacogenomics J. 2012 Feb;12(1):30-44. doi: 10.1038/tpj.2010.60. Epub 2010 Jul 20. PubMed PMID: 20644563; PMC3000876.

13: Han F, Yu H, Li P, Zhang J, Tian C, Li H, Zheng QY. Mutation in Phex gene predisposes BALB/c-Phex(Hyp-Duk)/Y mice to otitis media.PLoS One. 2012;7(9):e43010. doi: 10.1371/journal.pone.0043010. Epub 2012 Sep 28. PubMed PMID: 23028440; PMC3461009.

14: Tian C, Yu H, Yang B, Han F, Zheng Y, Bartels CF, Schelling D, Arnold JE, Scacheri PC, Zheng QY. Otitis media in a new mouse model for CHARGE syndrome with a deletion in the Chd7 gene. PLoS One. 2012;7(4):e34944. doi: 10.1371/journal.pone.0034944. Epub 2012 Apr 23. PubMed PMID: 22539951; PMC3335168.

15: Huang Q, Zhang Z, Zheng Y, Zheng Q, Chen S, Xu Y, Ou Y, Qiu Z. Hypoxia-inducible factor and vascular endothelial growth factor pathway for the study of hypoxia in a new model of otitis media with effusion. Audiol Neurootol. 2012;17(6):349-56. doi: 10.1159/000341163. Epub 2012 Aug 15. PubMed PMID: 22907120; PMC3637049.

16: Li SL, Zhang MY, Li BY, Zheng QY, Zhu HL. [Toll-like receptor 2 and Toll-like receptor 4 participates in mediation of acute otitis media and mortality in pneumococcal infections in mice]. Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2011 Dec;46(12):1009-18. Chinese. PubMed PMID: 22336013.

17: Ji YB, Han DY, Lan L, Wang DY, Zong L, Zhao FF, Liu Q, Benedict-Alderfer C, Zheng QY, Wang QJ. Molecular epidemiological analysis of mitochondrial DNA12SrRNA A1555G, GJB2, and SLC26A4 mutations in sporadic outpatients with nonsyndromic sensorineural hearing loss in China. Acta Otolaryngol. 2011 Feb;131(2):124-9. doi: 10.3109/00016489.2010.483479. Epub 2010 Dec 16. PubMed PMID: 21162657; PMC3528947.

18: Yang B, Tian C, Zhang ZG, Han FC, Azem R, Yu H, Zheng Y, Jin G, Arnold JE, Zheng QY. Sh3pxd2b mice are a model for craniofacial dysmorphology and otitis media. PLoS One. 2011;6(7):e22622. doi: 10.1371/journal.pone.0022622. Epub 2011 Jul 27. PubMed PMID: 21818352; PMC3144925.

19: Wong BK, Hossain SM, Trinh E, Ottmann GA, Budaghzadeh S, Zheng QY, Simpson EM. Hyperactivity, startle reactivity and cell-proliferation deficits are resistant to chronic lithium treatment in adult Nr2e1(frc/frc) mice. Genes Brain Behav. 2010 Oct;9(7):681-94. doi: 10.1111/j.1601-183X.2010.00602.x. Epub 2010 Jun 21. PubMed PMID: 20497236; PMC3292041.

20: Jin G, Kawsar HI, Hirsch SA, Zeng C, Jia X, Feng Z, Ghosh SK, Zheng QY, Zhou A, McIntyre TM, Weinberg A. An antimicrobial peptide regulates tumor-associated macrophage trafficking via the chemokine receptor CCR2, a model for tumorigenesis. PLoS One. 2010 Jun 8;5(6):e10993. doi: 10.1371/journal.pone.0010993. PubMed PMID: 20544025; PMC2882331.

21: Wang DY, Wang YC, Weil D, Zhao YL, Rao SQ, Zong L, Ji YB, Liu Q, Li JQ, Yang HM, Shen Y, Benedict-Alderfer C, Zheng QY, Petit C, Wang QJ. Screening mutations of OTOF gene in Chinese patients with auditory neuropathy, including a familial case of temperature-sensitive auditory neuropathy. BMC Med Genet. 2010 May 26;11:79. doi: 10.1186/1471-2350-11-79. PubMed PMID: 20504331; PMC2901213.

22: Tian C, Liu XZ, Han F, Yu H, Longo-Guess C, Yang B, Lu C, Yan D, Zheng QY. Ush1c gene expression levels in the ear and eye suggest different roles for Ush1c in neurosensory organs in a new Ush1c knockout mouse. Brain Res. 2010 Apr 30;1328:57-70. doi: 10.1016/j.brainres.2010.02.079. Epub 2010 Mar 6. PubMed PMID: 20211154; PMC2907663.

23: Chance MR, Chang J, Liu S, Gokulrangan G, Chen DH, Lindsay A, Geng R, Zheng QY, Alagramam K. Proteomics, bioinformatics and targeted gene expression analysis reveals up-regulation of cochlin and identifies other potential biomarkers in the mouse model for deafness in Usher syndrome type 1F. Hum Mol Genet. 2010 Apr 15;19(8):1515-27. doi: 10.1093/hmg/ddq025. Epub 2010 Jan 22. PubMed PMID: 20097680; PMC2846161.

24: Han F, Yu H, Zhang J, Tian C, Schmidt C, Nava C, Davisson MT, Zheng QY. Otitis media in a mouse model for Down syndrome. Int J Exp Pathol. 2009 Oct;90(5):480-8. doi: 10.1111/j.1365-2613.2009.00677.x. PubMed PMID: 19765102; PMC2768146.

25: Zheng QY, Ding D, Yu H, Salvi RJ, Johnson KR. A locus on distal chromosome 10 (ahl4) affecting age-related hearing loss in A/J mice.Neurobiol Aging. 2009 Oct;30(10):1693-705. doi: 10.1016/j.neurobiolaging.2007.12.011. Epub 2008 Feb 14. PubMed PMID: 18280008; PMC2756338.

26: Mao M, Thedens DR, Chang B, Harris BS, Zheng QY, Johnson KR, Donahue LR, Anderson MG. The podosomal-adaptor protein SH3PXD2B is essential for normal postnatal development. Mamm Genome. 2009 Aug;20(8):462-75. doi: 10.1007/s00335-009-9210-9. Epub 2009 Aug 8. PubMed PMID: 19669234; PMC2759419.

27: Han F, Yu H, Tian C, Li S, Jacobs MR, Benedict-Alderfer C, Zheng QY. Role for Toll-like receptor 2 in the immune response to Streptococcus pneumoniae infection in mouse otitis media. Infect Immun. 2009 Jul;77(7):3100-8. doi: 10.1128/IAI.00204-09. Epub 2009 May 4. PubMed PMID: 19414550; PMC2708554.

28: Alagramam KN, Brown SD, Davis RR, Johnson KR, Jones SM, Macauley JB, Zheng QY, Zuo J. Foreword for special issue: mouse models for hearing research. Brain Res. 2009 Jun 24;1277:1-2. doi: 10.1016/j.brainres.2009.05.048. PubMed PMID: 19540992.

29: Trune DR, Zheng QY. Mouse models for human otitis media. Brain Res. 2009 Jun 24;1277:90-103. doi: 10.1016/j.brainres.2009.02.047. Epub 2009 Mar 6. Review. PubMed PMID: 19272362; PMC2832702.

30: Sheykholeslami K, Megerian CA, Zheng QY. Vestibular evoked myogenic potentials in normal mice and Phex mice with spontaneous endolymphatic hydrops. Otol Neurotol. 2009 Jun;30(4):535-44. doi: 10.1097/MAO.0b013e31819bda13. PubMed PMID: 19300299; PMC2828446.

31: Liu S, Sun MZ, Sun C, Zhao B, Greenaway FT, Zheng Q. A novel serine protease from the snake venom of Agkistrodon blomhoffii ussurensis. Toxicon. 2008 Dec 1;52(7):760-8. doi: 10.1016/j.toxicon.2008.08.012. Epub 2008 Sep 9. PubMed PMID: 18817802; PMC2845635.

32: Johnson KR, Longo-Guess C, Gagnon LH, Yu H, Zheng QY. A locus on distal chromosome 11 (ahl8) and its interaction with Cdh23 ahl underlie the early onset, age-related hearing loss of DBA/2J mice. Genomics. 2008 Oct;92(4):219-25. doi: 10.1016/j.ygeno.2008.06.007. Epub 2008 Aug 15. PubMed PMID: 18662770; PMC2836023.

33: Tsuchiya K, Komori M, Zheng QY, Ferrieri P, Lin J. Interleukin-10 is an essential modulator of mucoid metaplasia in a mouse otitis media model. Ann Otol Rhinol Laryngol. 2008 Aug;117(8):630-6. PubMed PMID: 18771082; PMC2692729.

34: Liu S, Zhang S, Zheng QY, Li S. Mammalin cochlear supporting cells transdifferentiation into outer hair cells. ACADEMIC JOURNAL OF XI'AN JIAOTONG UNIVERSITY, http://www.case.edu/med/otolaryngology/LiBat.pdf. 2008 April; 20(4):256-261.

35: Megerian CA, Semaan MT, Aftab S, Kisley LB, Zheng QY, Pawlowski KS, Wright CG, Alagramam KN. A mouse model with postnatal endolymphatic hydrops and hearing loss. Hear Res. 2008 Mar;237(1-2):90-105. doi: 10.1016/j.heares.2008.01.002. Epub 2008 Jan 15. PubMed PMID: 18289812; PMC2858221.

36: Li S, Zhang SQ, Liu SW, Li BY, Zhu HL, Yu H, Zheng QY. Assessment criteria for rotated stereociliary bundles in the guinea pig cochlea.Otol Neurotol. 2008 Jan;29(1):86-92. doi: 10.1097/mao.0b013e31815dbb5b. PubMed PMID: 18199962; PMC2832703.

37: Zheng QY, Tong YC, Alagramam KN, Yu H. Tympanometry assessment of 61 inbred strains of mice. Hear Res. 2007 Sep;231(1-2):23-31. Epub 2007 Jun 2. PubMed PMID: 17611057; PMC2000814.

38: Zhang J, Kaga K, Zheng QY. Small papillary tumor in the saccule. Int J Pediatr Otorhinolaryngol Extra. 2007 Jun;2(2):107-110. PubMed PMID: 19098998; PMC2605686.

39: Zheng QY, Yu H, Washington JL 3rd, Kisley LB, Kikkawa YS, Pawlowski KS, Wright CG, Alagramam KN. A new spontaneous mutation in the mouse protocadherin 15 gene. Hear Res. 2006 Sep;219(1-2):110-20. Epub 2006 Aug 2. PubMed PMID: 16887306; PMC2855306.

40: Jones SM, Jones TA, Johnson KR, Yu H, Erway LC, Zheng QY. A comparison of vestibular and auditory phenotypes in inbred mouse strains. Brain Res. 2006 May 26;1091(1):40-6. Epub 2006 Feb 24. PubMed PMID: 16499890; PMC2859199.

41: Johnson KR, Zheng QY, Noben-Trauth K. Strain background effects and genetic modifiers of hearing in mice. Brain Res. 2006 May 26;1091(1):79-88. Epub 2006 Mar 31. Review. PubMed PMID: 16579977; PMC2858224.

42: Zheng QY, Hardisty-Hughes R, Brown SD. Mouse models as a tool to unravel the genetic basis for human otitis media. Brain Res. 2006 May 26;1091(1):9-15. Review. PubMed PMID: 16917982; PMC2855297.

43: Zhou X, Jen PH, Seburn KL, Frankel WN, Zheng QY. Auditory brainstem responses in 10 inbred strains of mice. Brain Res. 2006 May 26;1091(1):16-26. Epub 2006 Mar 3. PubMed PMID: 16516865; PMC2859191.

44: Zheng QY, Rozanas CR, Thalmann I, Chance MR, Alagramam KN. Inner ear proteomics of mouse models for deafness, a discovery strategy. Brain Res. 2006 May 26;1091(1):113-21. Epub 2006 Apr 5. Review. PubMed PMID: 16600193; PMC2853763.

45: Zhang JP, Peng ZH, Zhang J, Zhang XH, Zheng QY. Helicobacter pylori infection in the pharynx of patients with chronic pharyngitis detected with TDI-FP and modified Giemsa stain. World J Gastroenterol. 2006 Jan 21;12(3):468-72. PubMed PMID: 16489652; PMC2855301.

46: Keithley EM, Canto C, Zheng QY, Wang X, Fischel-Ghodsian N, Johnson KR. Cu/Zn superoxide dismutase and age-related hearing loss.Hear Res. 2005 Nov;209(1-2):76-85. Epub 2005 Aug 1. PubMed PMID: 16055286; PMC2858225.

47: Zhang J, Peng Z, Yang M, Zhang X, Wei J, Xu M, Zheng QY. Observation of the morphology and calcium content of vestibular otoconia in rats after simulated weightlessness. Acta Otolaryngol. 2005 Oct;125(10):1039-42. PubMed PMID: 16298783; PMC2858292.

48: Collin GB, Cyr E, Bronson R, Marshall JD, Gifford EJ, Hicks W, Murray SA, Zheng QY, Smith RS, Nishina PM, Naggert JK. Alms1-disrupted mice recapitulate human Alström syndrome. Hum Mol Genet. 2005 Aug 15;14(16):2323-33. Epub 2005 Jul 6. PubMed PMID: 16000322; PMC2862911.

49: Longo-Guess CM, Gagnon LH, Cook SA, Wu J, Zheng QY, Johnson KR. A missense mutation in the previously undescribed gene Tmhs underlies deafness in hurry-scurry (hscy) mice. Proc Natl Acad Sci U S A. 2005 May 31;102(22):7894-9. Epub 2005 May 19. PubMed PMID: 15905332; PMC1142366.

50: Johnson KR, Zheng QY, Weston MD, Ptacek LJ, Noben-Trauth K. The Mass1frings mutation underlies early onset hearing impairment in BUB/BnJ mice, a model for the auditory pathology of Usher syndrome IIC. Genomics. 2005 May;85(5):582-90. PubMed PMID: 15820310; PMC2855294.

51: Zheng QY, Yan D, Ouyang XM, Du LL, Yu H, Chang B, Johnson KR, Liu XZ. Digenic inheritance of deafness caused by mutations in genes encoding cadherin 23 and protocadherin 15 in mice and humans. Hum Mol Genet. 2005 Jan 1;14(1):103-11. Epub 2004 Nov 10. PubMed PMID: 15537665; PMC2858222.

52: Zheng QY, Harris BS, Ward-Bailey PF, Yu H, Bronson RT, Davisson MT, Johnson KR. Fine Mapping of a Deafness Mutation hml on Mouse Chromosome 10. Acad J Xian Jiaotong Univ. 2004 Jun;25(3):209-212. PubMed PMID: 21179397; PMC3004367.

53: Lorenz-Depiereux B, Guido VE, Johnson KR, Zheng QY, Gagnon LH, Bauschatz JD, Davisson MT, Washburn LL, Donahue LR, Strom TM, Eicher EM. New intragenic deletions in the Phex gene clarify X-linked hypophosphatemia-related abnormalities in mice. Mamm Genome. 2004 Mar;15(3):151-61. PubMed PMID: 15029877; PMC2859190.

54: Keithley EM, Canto C, Zheng QY, Fischel-Ghodsian N, Johnson KR. Age-related hearing loss and the ahl locus in mice. Hear Res. 2004 Feb;188(1-2):21-8. PubMed PMID: 14759567; PMC2858220.

55: Johnson KR, Gagnon LH, Webb LS, Peters LL, Hawes NL, Chang B, Zheng QY. Mouse models of USH1C and DFNB18: phenotypic and molecular analyses of two new spontaneous mutations of the Ush1c gene. Hum Mol Genet. 2003 Dec 1;12(23):3075-86. Epub 2003 Sep 30. PubMed PMID: 14519688; PMC2862298.

56: Donahue LR, Chang B, Mohan S, Miyakoshi N, Wergedal JE, Baylink DJ, Hawes NL, Rosen CJ, Ward-Bailey P, Zheng QY, Bronson RT, Johnson KR, Davisson MT. A missense mutation in the mouse Col2a1 gene causes spondyloepiphyseal dysplasia congenita, hearing loss, and retinoschisis. J Bone Miner Res. 2003 Sep;18(9):1612-21. Erratum in: J Bone Miner Res. 2007 Dec;22(12):2011. PubMed PMID: 12968670; PMC2862909.

57: Noben-Trauth K, Zheng QY, Johnson KR. Association of cadherin 23 with polygenic inheritance and genetic modification of sensorineural hearing loss. Nat Genet. 2003 Sep;35(1):21-3. Epub 2003 Aug 10. PubMed PMID: 12910270; PMC2864026.

58: Johnson KR, Zheng QY. Ahl2, a second locus affecting age-related hearing loss in mice. Genomics. 2002 Nov;80(5):461-4. PubMed PMID: 12408962; PMC2862211.

59: Young KA, Berry ML, Mahaffey CL, Saionz JR, Hawes NL, Chang B, Zheng QY, Smith RS, Bronson RT, Nelson RJ, Simpson EM.Fierce: a new mouse deletion of Nr2e1; violent behaviour and ocular abnormalities are background-dependent. Behav Brain Res. 2002 May 14;132(2):145-58. PubMed PMID: 11997145; PMC2862907.

60: Ikeda A, Zheng QY, Zuberi AR, Johnson KR, Naggert JK, Nishina PM. Microtubule-associated protein 1A is a modifier of tubby hearing (moth1). Nat Genet. 2002 Apr;30(4):401-5. Epub 2002 Feb 4. PubMed PMID: 11925566; PMC2862212.

61: Staecker H, Zheng QY, Van De Water TR. Oxidative stress in aging in the C57B16/J mouse cochlea. Acta Otolaryngol. 2001 Sep;121(6):666-72. PubMed PMID: 11678164; PMC2862210.

62: Zheng QY, Johnson KR. Hearing loss associated with the modifier of deaf waddler (mdfw) locus corresponds with age-related hearing loss in 12 inbred strains of mice. Hear Res. 2001 Apr;154(1-2):45-53. PubMed PMID: 11423214; PMC2881674.

63: Johnson KR, Zheng QY, Bykhovskaya Y, Spirina O, Fischel-Ghodsian N. A nuclear-mitochondrial DNA interaction affecting hearing impairment in mice. Nat Genet. 2001 Feb;27(2):191-4. PubMed PMID: 11175788; PMC2862214.

64: Johnson KR, Zheng QY, Erway LC. A major gene affecting age-related hearing loss is common to at least ten inbred strains of mice.Genomics. 2000 Dec 1;70(2):171-80. PubMed PMID: 11112345.

65: Letts VA, Valenzuela A, Dunbar C, Zheng QY, Johnson KR, Frankel WN. A new spontaneous mouse mutation in the Kcne1 gene. Mamm Genome. 2000 Oct;11(10):831-5. PubMed PMID: 11003695; PMC2862908.

66: Munroe RJ, Bergstrom RA, Zheng QY, Libby B, Smith R, John SW, Schimenti KJ, Browning VL, Schimenti JC. Mouse mutants from chemically mutagenized embryonic stem cells. Nat Genet. 2000 Mar;24(3):318-21. PubMed PMID: 10700192; PMC2868360.

67: Ikeda A, Zheng QY, Rosenstiel P, Maddatu T, Zuberi AR, Roopenian DC, North MA, Naggert JK, Johnson KR, Nishina PM. Genetic modification of hearing in tubby mice: evidence for the existence of a major gene (moth1) which protects tubby mice from hearing loss.Hum Mol Genet. 1999 Sep;8(9):1761-7. PubMed PMID: 10441341; PMC3249642.

68: Zheng QY, Johnson KR, Erway LC. Assessment of hearing in 80 inbred strains of mice by ABR threshold analyses. Hear Res. 1999 Apr;130(1-2):94-107. PubMed PMID: 10320101; PMC2855304.

69: Johnson KR, Cook SA, Zheng QY. The original shaker-with-syndactylism mutation (sy) is a contiguous gene deletion syndrome. Mamm Genome. 1998 Nov;9(11):889-92. PubMed PMID: 9799839; PMC2858217.

70: Zheng QY, Johnson KR, Erway LC. Screening mice at The Jackson Laboratory for hereditary hearing impairment. Hereditary Deafness Newsletter. 1998 June; 15:13-18.

71: Johnson KR, Erway LC, Cook SA, Willott JF, Zheng QY. A major gene affecting age-related hearing loss in C57BL/6J mice. Hear Res. 1997 Dec;114(1-2):83-92. PubMed PMID: 9447922.

72: Lu Y, Jen PH, Zheng QY. GABAergic disinhibition changes the recovery cycle of bat inferior collicular neurons. J Comp Physiol A. 1997 Oct;181(4):331-41. PubMed PMID: 9342856; PMC2862906.

73: Noben-Trauth K, Zheng QY, Johnson KR, Nishina PM. mdfw: a deafness susceptibility locus that interacts with deaf waddler (dfw).Genomics. 1997 Sep 15;44(3):266-72. PubMed PMID: 9325047.

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Books and Chapters

81: Zheng QY, Johnson KR. Recent Advances in Otitis Media. Hamilton, Ontario L8N 2B9, Canada: BC Decker publisher; 2003. Genetic Mouse Models of Otitis Media. 381-385p.

82: Johnson KR, Zheng QY, Letts VA. Handbook of Mouse Auditory Research: from Behavior to Molecular Biology. Willott JF editor. Boca Raton, Florida, USA: CRC Press; 2001. Genetic Analyses of Non-transgenic Mouse Mutations Affecting Ear Morphology or Function. 429-440p.

83: Erway LC, Zheng QY, Johnson KR. Handbook of Mouse Auditory Research: from Behavior to Molecular Biology. Willott JF editor. Boca Raton, Florida, USA: CRC Press; 2001. Genetics of Age-related Hearing Loss in Inbred Strains of Mice; p.401-428. 401-428p.

Lab members

Cindy Benedict-Alderfer , Ph.D. Research Specialist
Heping Yu , BS, Research Assistant 4
Benjamin Cherry, CWRU medical student
Fenchan Han , MD, Ph.D. Postdoctoral Research Associate
Cong Tian , B.S., Research Associate
Hui Chen, CWRU student, Under-Graduate, Biology Major
Bin Yang, DMD, MS, Graduate Student
Hongbo Li, MD, Visiting Physician
 Fei Han, MD, Visiting Associate Professor
Aparna Swaminathan, CWRU medical student