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Policies and Resources - Pain Classification |
Class C: Pain or distress will be absent or minimal and momentary
Description:
Testing, teaching, or experiments involving no pain, distress, or use of pain relieving mediciations. Again, recognize that pain or distress must be more than
slight or momentary to be, be definition, a painful procedure.
Example: Collection of blood sample from a peripheral vein not resulting in pain or distress.
This category includes but is not limited to:
Breeding.
Gavage.
Tissue collection after euthanasia.
Most injections, if the injection does not introduce an agent which causes pain or distress.
Blood collection from a peripheral vein.
The use of Freund's complete adjuvant in immunizations in accord with IACUC policy:
Freunds Adjuvant Policy
Nutritional studies if they do not lead to debilitation of the animal.
Subclinical infections.
Procedures which cause only minor discomfort.
Tumor studies in rodents whithin the IACUC-recommended limit.
Class D: Pain or distress will be present and appropriate anesthetics, analgesics or tranquilizers will be provided.
Description: Testing, teaching or experiments involving pain or distress for which appropriate analgesic, anesthetic or tranquilizing drugs are used.
Examples: Use of an anesthetic agent to prevent pain or distress associated with intercardiac blood collection. The use of a therapeutic agent to remedy an intentionally induced disease process.
This catefory includes but is not limitied to:
Terminal tissue or organ harvest under anesthesia.
Pithing or exsanguination under anesthesia
Surgeries such as biopsy, gonadectomy, exposure of blood vessels, chronic catheter implantation, bronchoalvcolor lavage, laparotomy or laparoscopy when performed with appropriate anesthesia and alalgesia.
Surgical invasion of body cavaties, orthopedic procedures, denistry or other hard or soft tissue damage when performed with appropriate anesthesia and analgesia.
Blood collection by invasive procedures such as intracardiac or periorbital collection from species without a true orbital sinus such as rats and guinea pigs when performed with appropriate anesthesia.
Blood collection from the periorbital sinus of mice when performed with appropriate anesthesia.
Class E: Pain or distress will be induced and will not be relieved because relief would interfere with procedures, results or interpretation of the results.
Description: Teaching, testing or experiments involving pain or distress from which the use of appropriate anesthetic, analgesics or tranquilizing drugs would have adversely affected the procedures results or the interpretation.
Examples: Collection of an inter-cardiac blood sample without the use of pain-relieving medications. The presence of an experimentally induced disease process that causes pain or distress that is not relieved by the use of pain-relieving medications.
This category includes but is not limited to:
Adminstration of chemicals or agents which produce pain or distress which is not relieved with analgesics.
Mutants with chronic pain or debilitation which is not relieved with analgesics or by appropriate intervention.
Procedures producing pain or distress unrelieved by analgesics such as toxicity studies, microbial virulence testing, radiation sickness studies and research on stress, shock or pain.
Prolonged restraint without appropriate measures to alleviate distress.
The administration of Freund's complete adjuvant by means not accord with IACUC policy:
Freunds Adjuvant Policy
Studies where the death of an animal is an experimental endpoint. Investigators should consider that pain relief may be incomplete despite best efforts to provide analgesia. In such cases, it may be appropriate to categorize the procedure as Class E.
Where appropriate, the experience of humans subject to the same conditions can be used as a guide to a classfication.
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