Case Western Reserve School of Medicine Core Facilities Newsletter

difficulty seeing this information? view this newsletter online.

Case Western Reserve University School of Medicine
School of Medicine Core Facilities Newsletter Volume 20

A Healthy Core Facility Ecosystem

Introduction

The School of Medicine's healthy Core Facility ecosystem enables cutting edge research by our scientific investigators in our Departments and Major Centers. There are more than 30 Cores in the SOM providing research services and expertise that range the full spectrum of capabilities from bench to bedside. In this relaunched Core Facilities Newsletter you will hear about the work being done by your Core Facility Steering Committee and Office of Research Administration to continue building this resource, including the CrossLab/iLab project, the Core Facilities Investment project. You will also learn about new Core Facilities that have been brought online and receive announcements about future Core Facility events. To find out more about Core Facilities, you can visit https://research.case.edu/corefacilities/SOM or contact Matt DeVries, the School's Core Facility Specialist (mpd35@case.edu, 368-1266).

Crosslab (formerly iLab)

Case Western Reserve University is excited to announce our implementation of Agilent Technology’s CrossLab (Formerly iLab) Core Facility Management software, an online system to streamline access and discoverability of our core facilities, as well as ease ordering and billing for core service requests. The first wave of Core Facilities will be going live in the system. That group is The Genomics Core led by Alex Miron, Imaging Research Core led by Christopher Flask, and Cytometry and Imaging Microscopy Core led by James Jacobberger.

Customers of those cores will be able to access the Core Facilities beginning in April with a few select users, and all users by the end of the month, to schedule instrument time, to order services, to submit projects, and to solicit consultation/assistance with experimental design. The plan is to have 20 Core Facilities using the system by the end of 2017. CrossLab will utilize CWRU’s Single Sign-On, so no need for a separate account, and will be fully integrated with CWRU’s Financial Software Peoplesoft, giving users up to date access and usage of their SpeedTypes, and the ability to manage who in the laboratories have access to their SpeedTypes.

If you have questions about iLab, please contact Matt DeVries (mpd35@case.edu, 368-1266)

--The iLab CrossLab Implementation Team Matt DeVries and Kathryn Iwamasa (UTech Project Manager)


Core Facility Feature - Imaging Research Core

There are a large variety of Core Facilities in the School, with some that were founded and primarily serve NIH Center Grant Members, Cores that only serve specific departments, and those who service the whole of the SOM Research Community supporting many major centers and departments. The term for these are Institutional Core Facilities and there are 8 of those in the School. We want to use this space to feature some the cutting edge science the facilities are making possible.

The Imaging Research Core Facility is well into its second decade and is led by Christopher Flask, a member of the Cancer Center and Biomedical Engineering. The Facility provides a comprehensive suite of preclinical and clinical imaging instrumentation and techniques developed in-house. In the past fiscal year, the Imaging Research Core provided support to more than $26M in total-to-date funding for approximately 50 principal investigators throughout CWRU and UHCMC. Federal funding, including R01, R21, U01-level NIH awards, DOD, and NSF awards accounted for approximately 82% of the total funding support. The Imaging Research Core collected nearly $400,000 in chargeback fees with 83% coming from internal sources. The Core issupported as a Shared Resource of the Case Comprehensive Cancer Center, Digestive Diseases Research Center, the Cystic Fibrosis Foundation, and the Clinical Translational Science Collaborative.

  • Dedicated animal facility
  • State-of-the-art imaging capabilities spanning the entire range from molecular and preclinical imaging services to clinical and translational research studies
  • Dedicated workstations for data processing
  • Bruker Biospec 7.0T and 9.4T in vivo small animal magnetic resonance imaging (MRI) scanners
  • Perkin-Elmer IVIS Spectrum In Vivo Imaging System
  • Cri Maestro scanner
  • Perkin-Elmer Fluorescence MicroTomography System
  • CryoFlouroscence Imaging System.
  • Preclinical PET/CT
  • Single photon emission tomography (SPECT)/CT, and planar X-ray capabilities
  • Radiopharmaceutical and Cold Synthesis
  • F-18 and C11 radiotracers and F-18 or C-11 radiolabeling of individual developmental compounds
    • Announcements

      Save the Date: 5th Annual Core Facilities Retreat and Symposium, September 7th, 9am. Agenda and sponsorship to be announced.

      Core facilities Investment Project

      In the Summer of 2016 the Core Facilities Steering Committee (CSC) put out an RFI to Core Facility Directors to write a one page proposal for new technologies that School of Medicine currently lacks which could move our scientific mission ahead with the greatest impact. We received 29 proposals which were reviewed by the Strategy and Investment working group and the Office of Research Administration. Eleven of the those proposals were scored as having the highest potential impact based on Scientific Novelty, Potential CWRU User Base, Scientific Need, and Business Plan. The CSC and SOM:ORA are now moving ahead with the submitters of the those proposals to identify an appropriate funding strategies to bring those new technologies to our researchers.

      New Core Facilities

      Preclinical Antimicrobial Testing Core - Director: Mahmood Ghannoum (mag3@case.edu) An institutional resource through Case Western Reserve University offering preclinical, clinical and translational services to bring anti-infective agents from discovery to market – from test-tube to patient. Services are available to the pharmaceutical/Biotech industry, research community and clinicians to support drug development in all FDA required testing phases to satisfy Investigational New Drug (IND) and New Drug Application (NDA) submissions. As pharmaceutical and biotech companies are relying more heavily on outsourcing research and development, the PATC can provide experts and resources for pre-clinical evaluation for anti-infectives under development.

      Animate Skills Laboratory - Director: Steve Schomisch (sjs12@case.edu) The Animate Skills Laboratory at Case Western Reserve University is located in the School of Medicine, Biomedical Research Building. This Core facility provides surgical resources to facilitate education, training, research and innovation for CWRU medical students, residents, UHHS and affiliate hospital healthcare personnel, the CWRU investigative community, as well as industry partners. Our directive is to enhance the training and academic achievements of our surgeons and those from other health care institutes. The laboratory uses a range of animal models, both large and small, and human cadavers to conduct research in the field of minimally invasive surgical procedures and to coordinate animate training courses to allow "hands on" training for the surgical residents, fellows and attending surgeons.

      If you have questions, suggestions, or requests for future newsletters, please contact Core Facilities Specialist Matt DeVries in the Office of Research Administration (mpd35@case.edu, 368-1266)

      This newsletter was prepared by the Core Steering Committee Visibility Working Group led by Gillian Irwin, and with members Shannon Swiatkowski, Craig Hodges, and Matt DeVries.

    Copyright © 2017 Case Western Reserve University