Visual Science Proteomics Core Module Spectrometry
Visual Sciences Research Center
Institute of Pathology, VSRC Consolidated Laboratory Space
Benlian Wang, PhD, Facility Manager
Krzysztof Palczewski, PhD, Director, Scientific Advisor
Masaru Miyagi, PhD, Co-Director, Scientific Advisor
Contact:
Serves: Visual research scientists interested in carrying out proteomic studies and mass spectrometry analysis of bio-molecules
Overview
A powerful combination of protein separation techniques (two-dimensional gel electrophoresis and multi-dimensional high performance liquid chromatography), protein structural characterization techniques (mass spectrometry) and bioinformatics tools to link mass spectrometry data with genome database constitute the backbone of a newly emerged technology "proteomics". Current proteomic studies have three major categories 1) expression proteomics, 2) post-translational modification proteomics and 3) interaction proteomics as described below. The Proteomics Module will provide technical support for carrying out the three categories of proteomic studies as well as standard mass spectrometry analysis of bio-molecules for the vision research scientists at the Case Western Reserve University. Case Western Reserve University is already equipped with research resources to carry out proteomic studies, including state-of-the-art mass spectrometers, protein separation systems (both multi-dimensional HPLC and 2D-PAGE) and bioinformatics tools within the Center for Proteomics (http://casemed.case.edu/proteomics), directed by Dr. Mark Chance. The Visual Science Research Center in the past year has formed a partnership with the Center for Proteomics to utilize the resources effectively for the vision scientists at Case and proposes to strengthen this relationship with the renewal of the P30 Core Grant. The module director, Dr. Krzysztof Palczewski, Professor and Chair of the Department of Pharmacology, the module co-director, Dr. Masaru Miyagi, Assistant Professor in the Center for Proteomics, Ophthalmology, and Pharmacology, and the module manager, Dr. Benlian Wang, will lead this effort. Together they will be a bridge between the Visual Science Research Center and the Center for Proteomics to facilitate the use of proteomic approaches for the vision scientists at Case.
Page last updated: August, 2007
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