Animal Experimentation Core
Skin Diseases Research Center, Dermatology Department
Thomas S. McCormick, PhD, Facility Director
Contact:
Serves: Department Only
Overview
The Animal Core facilitates investigator use of development of animal models of skin disease. Creation of new models of diseased skin, characterization of transgenic and knock-out mice, and skin cancer models using UV simulated solar radiation, and chemical mortagenesis/initiation, and promotion are all popular programs among the Core users. Quality procurement, handling, and interpretation of spontaneous phenotypes or those that are elicited via barrier description, contact dermatitis, UV, or microorganisms, or or production of skin and skin tumors facilitates histology, homegenates, and/or cell suspensions, RNA, and DNA that can be used in flow cytometry, microarray, or proteomic experiments. Experience with athymic nude and SCID mice enhances experimentation in tissue implantation models, either using murine tumor cells or xenogenic transplants of human diseased skin. Also new is a panel of wounding/healing techniques, and assistance in applying small animal imaging/animal handling to skin models.
Page last updated: October, 2007
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216-368-0238
