Case Western Reserve School of Medicine Core Facilities Newsletter
Case Western Reserve University School of Medicine

office of translation and innovation
March 13, 2015

Two Faculty Receive National Innovation Award

From National Center for Accelerated Innovations

Innovation is a skill in high demand in academic medicine. Fortunately at Case Western Reserve University (CWRU) and University Hospitals (UH) Case Medical Center we have many faculty who are nationally recognized for their innovative research and their dedication to translational medicine. But, you don’t have to take my word for it. The National Center for Accelerated Innovation (NCAI), a grant program funded by the NIH and managed as a partnership between the Cleveland Clinic, CWRU, UH Case Medical Center, and institutions across the state, recently awarded funds to Drs. Saptarsi Haldar and Carlos Subauste to help accelerate promising technologies developed in their laboratories. The NIH’s Heart Lung and Blood Institute developed the NCAI program to increase the generation of new, patient benefiting products related to priority targets in the heart, lung, blood and sleep disorders space. Our Ohio consortium has established an efficient infrastructure to propel early-stage projects forward and to engage and educate researchers to be full partners in transforming their discoveries into high-impact advances in patient care.

Dr. Haldar is an Assistant Professor of Medicine in the Case Cardiovascular Research Institute, and his research centers on the development of BET bromodomain inhibitor drugs for human heart failure. These bromodomain proteins are critical mediators of pathologic cardiac hypertrophy and heart failure pathogenesis. Dr. Haldar's team will use the award to develop inhibitors as a novel therapeutic strategy in human heart failure, in both pre-clinical and first-in-human studies. His award will be matched by funds from the Prentiss Strong Heart Program.

Dr. Saptarsi Haldar, Assistant Professor, Case Cardiovascular Research Institute

Dr. Subauste is an Associate Professor of Medicine, Ophthalmology and Pathology and an infectious disease specialist with UH Case Medical Center. Dr. Subauste's research is focused on inhibition of CD40-TRAF signaling for the treatment of vascular inflammatory disorders, and he will use his award to synthesize and test the CD40-TRAF inhibitor in pre-clinical models of inflammation. His award will be matched by funds from the Council to Advance Human Health Accelerator Fund.

Dr. Carlos Subauste, Associate Professor of Medicine, Ophthalmology and Pathology, Division of Infectious Diseases

We expect more good news soon, as the NCAI recently solicited a third round of letters of intent. Thirty-five letters were received, of which 14 came from CWRU or UH Case Medical Center. This week, 12 investigators were invited to submit full proposals, 6 of them from CWRU/UH Case Medical Center. What a terrific performance from our faculty! If you don’t know about the NCAI program or want to learn about support for your inventions and innovation, please visit the SOM Office of Translation and Innovation website to see the wide range of opportunities and resources that are currently available to help you move your discoveries forward.

- Mark Chance, Vice Dean for Research

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