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Posted: January 3rd, 2012
The Case Western Reserve University School of Medicine community gathered to observe the inaugural appointment of Mark R. Chance, PhD, as the Dr. Charles W. and Iona A. Mathias Professor of Cancer Research on February 2, 2012.
Dr. Chance recently was appointed Vice Dean of Research at the School of Medicine, and he continues to lead multiple areas within the School of Medicine as Professor of General Medical Sciences, Director of the Center for Proteomics and Bioinformatics, Interim Chair of the Department of Genetics and Director of the Case Center for Synchrotron Biosciences. He also serves as Chief Scientific Officer and Co-Founder of NeoProteomics, Inc.
"In addition to being an outstanding scientist, Mark is an individual with remarkable strategic insight," remarked School of Medicine Dean Pamela B. Davis at the ceremony. "He has the ability to communicate complex ideas with eloquence and passion in a way that everyone can understand, and that has made him an exceptional collaborator within this school and throughout campus."
The Chance lab uses quantitative mass spectrometry and 2-D gel techniques in order to identify biomarkers and regulatory pathways in complex diseases such as cancer, diabetes and HIV infection. A major emphasis is placed on applying state-of-the art proteomics and systems biology tools to investigate HIV pathogenesis in the context of drug abuse, and provide significant biomarkers of cancer progression and response to therapy. The use of high-resolution mass spectrometry instruments of the Center, coupled to the advanced bioinformatics and biostatistical pipelines for analysis, provide quantitative label free protein expression analysis using a "shotgun" proteomics approach. Subsequent analysis using network and pathway tools provide novel insights into patho-physiological changes in disease. Dr. Chance's position as director of the proteomics center at Case has allowed multiple strategic partnerships to develop between NeoProteomics and key faculty working in a number of areas of human disease in the School of Medicine.
Dr. Chance received his PhD in Biophysics from the University of Pennsylvania in 1986. He spent a large portion of his career teaching at the Albert Einstein College of Medicine prior to joining Case Western Reserve School of Medicine and the Center for Proteomics and Bioinformatics in 2005.
Dr. Chance has received numerous awards including The Upjohn Company New Faculty Research Award and the Irma T. Hirschl Career Scientist Award. He has published over 200 manuscripts on his proteomics, mass spectrometry and bioinformatics research.