David Dean, Ph.D.

David Dean received his Ph.D. in Biological Anthropology at the City University of New York in 1993. He completed a post-doctoral fellowship in the Institute of Reconstructive Plastic Surgery in 1994 at the New York University School of Medicine before joining the faculty of the School of Medicine at Case Western Reserve University in Cleveland. He directs the Department of Neurological Surgery Imaging Laboratory. His research interests are in Computer-Assisted Surgery, skull (bone) tissue engineering, photodynamic therapy of glioma, and automated radiosurgery treatment planning.

Visitors and Deliveries
Bishop Building, Room S623
2074 Abington Road, Bishop S621
Cleveland, OH 44106 USA


Recent Publications

  • Song MJ, Dean D, Knothe Tate MK: Computational Modeling of Tissue Engineering Scaffolds as Delivery Devices for Mechanical and Mechanically Modulated Signals. Stud Mechanobiol Tissue Eng Biomater 10:127-143, 2013. DOI: 10.1007/8415_2012_138

  • Song MJ, Brady-Kalnay SM, McBride SH, Phillips-Mason P, Dean D, Knothe Tate ML: Mapping the mechanome of live stem cells using a novel method to measure local strain fields in situ at the fluid-cell interface. PLoS One 7(9):e43601, 2012.

  • Dean D, Wallace J, Siblani A, Wang MO, Kim K, Mikos AG, Fisher JP: Continuous digital light processing (cDLP): Highly accurate additive manufacturing of tissue engineered bone scaffolds. Virtual and Physical Prototyping 7(1):13-24, 2012.

  • Dean D, Oleinick NL, Wilson BC, Cohen ML, Belle V, Sloan AE: Glioblastoma Multiforme Clinical Trial Studies 5-Aminolevulinic Acid for Fluorescence-Guided Resection. Neurological Institute Journal 4(2):19-21, 2012.

  • Belle V, Anka A, Cross N, Thompson Paul, Mott E, Sharmaa R, Gray K, Zhang R, Xu Y, Sun J, Flask CA, Oleinick NL, Dean D: Dynamic Contrast Enhanced-Magnetic Resonance Imaging (DCE-MRI) of Photodynamic Therapy (PDT) Outcome and Associated Changes in the Blood-Brain Barrier Following Pc 4-PDT of Glioma in an Athymic Nude Rat Model. SPIE, Proceedings Photonics West 2012, 8207(82074T):1-9, 2012.

  • Dean D, Wallace J, Siblani A, Wang MO, Kim K, Mikos AG, Fisher JP: The Calibration of Continuous Digital Light Processing (cDLP) for the Highly Accurate Additive Manufacturing of Tissue Engineered Bone Scaffolds. In (Paulo Jorge Bártolo; Ana Cristina Soares de Lemos; António Marió Henriques Pereira; Artur Jorge Mateus; Ausenda Luís Avelar Mendes; Cyril do Santos; Dino Miguel Fernandes Freitas; Helena Maria Bártolo; Henrique de Amorim Almeida; Igor Marques dos Reis; Juliana Rosa Dias; Marco André Neves Domingos; Nuno Manuel Fernandes Alves; Ruben Filipe Brás Pereira; Tatiana Marisa Fernandes Patricío; Telma Margarida Dias Ferreira): Proceedings of the 5th International Conference on Advanced Research and Rapid Prototyping, Leiria, Portugal, 28 September-1 October 2011: "Innovative Developments in virtual and physical prototyping", CRC Press/Balkema (Taylor & Francis Group), Boca Raton, FL, pp. 57-66, 2012.

  • Kim K, Dean D, Wallace J, Breithaupt R, Mikos AG, Fisher JP: The influence of stereolithographic scaffold architecture and composition on osteogenic signal expression with rat bone marrow stromal cells. Biomaterials 32(15):3750-3763, 2011.

  • Kim K, Dean D, Lu A, Mikos AG, Fisher JP: Early osteogenic signal expression of rat bone marrow stromal cells is influenced by both hydroxyapatite nanoparticle content and initial cell seeding density in biodegradable nanocomposite scaffolds. Acta Biomater. 7:1249-1264, 2011.

  • Song MJ, Dean D, Knothe Tate ML: In situ spatiotemporal mapping of flow fields around seeded stem cells at the subcellular length scale. PLoS One. 5: pii: e12796, 2010.

  • Kim K, Yeatts A, Dean D, Fisher JP: Stereolithographic Bone Scaffold Design Parameters: Osteogenic Differentiation and Signal Expression. Tissue Eng Part B Rev. 16:523-539, 2010.

  • Anka A, Thompson P, Mott E, Sharma R, Zhang R, Cross N, Sun J, Flask CA, Oleinick NL, Dean D: Dynamic Contrast Enhanced-Magnetic Resonance Imaging (DCE-MRI) for the Assessment of Pc 4-Sensitized Photodynamic Therapy of a U87-derived Glioma Model in the Athymic Nude Rat. SPIE, Proceedings Photonics West 2010: Photonic Therapeutics and Diagnostics VI, 7548(75483X):1-8, 2010.

  • Dean D, Wallace J, Kim K, Mikos AG, Fisher JP: Stereolithographic Rendering of Low Molecular Weight Polymer Scaffolds for Bone Tissue Engineering. In (Paulo Jorge da Silva Bártolo; Ana Cristina Soares de Lemos ; António Marió Henriques Pereira; Artur Jorge dos Santos Mateus; Ausenda Luís Avelar Mendes; Carla Sofia Monteiro de Moura; Carlos Alexandre Bento Capela; Catarina Sofia Gaspar da Silva; Flávio André Carvalho Domingues; Helena Maria Coelho da Rocha Terreiro Galha Bártolo; Henrique de Amorim Almeida; Irene Sofia Carvalho Ferreira; João Manuel Matias; Nuno Manuel Fernandes Alves; Susana Cristina Serrano Fernandes Rodrigues): Proceedings of the 4th International Conference on Advanced Research and Rapid Prototyping, Leiria, Portugal, 6-10 October 2009: "Innovative Developments in Design and Manufacturing: Advanced research in virtual and rapid prototyping", CRC Press (Taylor & Francis), Boca Raton, FL, pp. 37-43, 2010.

  • Kim K, Dean D, Mikos AG, Fisher JP: Effect of Initial Cell Seeding Density on Early Osteogenic Signal Expression of Rat Bone Marrow Stromal Cells Cultured on Cross-Linked Poly(propylene fumarate) Disks. Biomacromolecules. 10:1810-1817, 2009.

  • Cross N, Varghai D, Flask CA, Feyes DK, Oleinick NL, Dean D: Optimal Gadolinium Dose Level for Magnetic Resonance Imaging (MRI) Contrast Enhancement of U87-derived Tumors in Athymic Nude Rats for the Assessment of Photodynamic Therapy. In (Nikiforos Kollias; Bernard Choi; Haishan Zeng; Reza S. Malek; Brian J-F. Wong; Justus F. R. Ilgner; Kenton W. Gregory; Guillermo J. Tearney; Laura Marcu; Henry Hirschberg; Steen J. Madsen, Eds.): Proceedings Photonics West 2009: Photonic Therapeutics and Diagnostics V, SPIE 7161(71612Y):1-10, 2009.

  • Dean D, Cross N, Varghai D, Oleinick NL, Flask CA: Functional Measures of Therapy Based on Radiological Imaging. In (Sensen CW, Hallgrımsson B, Eds.): Advanced Imaging in Biology and Medicine. Springer-Verlag: Berlin, pp. 427-438, 2009.

  • Varghai D, Covey K, Sharma R, Cross N, Feyes DK, Oleinick NL, Flask CA, Dean D: Monitoring Pc 4-mediated Photodynamic Therapy of U87 Tumors with Dynamic Contrast Enhanced-Magnetic Resonance Imaging (DCE-MRI) in the Athymic Nude Rat. Photonics West 2008: In (Nikiforos Kollias; Bernard Choi; Haishan Zeng; Reza S. Malek; Brian J. Wong; Justus F. R. Ilgner; Kenton W. Gregory; Guillermo J. Tearney; Henry Hirschberg; Steen J. Madsen, Eds.): Proceedings Photonics West 2008: Photonic Therapeutics and Diagnostics IV, SPIE 6842(68422P):1-9, 2008.

  • Kim K, Dean D, Wallace J, Breithaupt R, Mikos AG, Fisher JP. The influence of stereolithographic scaffold architecture and composition on osteogenic signal expression with rat bone marrow stromal cells. Biomaterials 32(15):3750-3763, 2011.

  • Kim K, Dean D, Lu A, Mikos AG, Fisher JP: Early osteogenic signal expression of rat bone marrow stromal cells is influenced by both hydroxyapatite nanoparticle content and initial cell seeding density in biodegradable nanocomposite scaffolds. Acta Biomater. 7:1249-1264, 2011

  • Song MJ, Dean D, Knothe Tate ML: In situ spatiotemporal mapping of flow fields around seeded stem cells at the subcellular length scale. PLoS One. 5: pii: e12796, 2010.

  • Kim K, Yeatts A, Dean D, Fisher JP: Stereolithographic Bone Scaffold Design Parameters: Osteogenic Differentiation and Signal Expression. Tissue Eng Part B Rev. 16:523-539, 2010.

  • Anka A, Thompson P, Mott E, Sharma R, Zhang R, Cross N, Sun J, Flask CA, Oleinick NL, Dean D: Dynamic Contrast Enhanced-Magnetic Resonance Imaging (DCE-MRI) for the Assessment of Pc 4-Sensitized Photodynamic Therapy of a U87-derived Glioma Model in the Athymic Nude Rat. SPIE, Proceedings Photonics West 2010: Photonic Therapeutics and Diagnostics VI, 7548(75483X):1-8, 2010.

  • Dean D, Wallace J, Kim K, Mikos AG, Fisher JP: Stereolithographic Rendering of Low Molecular Weight Polymer Scaffolds for Bone Tissue Engineering. In (Paulo Jorge da Silva Bártolo; Ana Cristina Soares de Lemos ; António Marió Henriques Pereira; Artur Jorge dos Santos Mateus; Ausenda Luís Avelar Mendes; Carla Sofia Monteiro de Moura; Carlos Alexandre Bento Capela; Catarina Sofia Gaspar da Silva; Flávio André Carvalho Domingues; Helena Maria Coelho da Rocha Terreiro Galha Bártolo; Henrique de Amorim Almeida; Irene Sofia Carvalho Ferreira; João Manuel Matias; Nuno Manuel Fernandes Alves; Susana Cristina Serrano Fernandes Rodrigues): Proceedings of the 4th International Conference on Advanced Research and Rapid Prototyping, Leiria, Portugal, 6-10 October 2009: "Innovative Developments in Design and Manufacturing: Advanced research in virtual and rapid prototyping", CRC Press (Taylor & Francis), Boca Raton, FL, pp. 37-43, 2010.

  • Cross N, Varghai D, Flask CA, Feyes DK, Oleinick NL, Dean D: Optimal Gadolinium Dose Level for Magnetic Resonance Imaging (MRI) Contrast Enhancement of U87-derived Tumors in Athymic Nude Rats for the Assessment of Photodynamic Therapy. In (Nikiforos Kollias; Bernard Choi; Haishan Zeng; Reza S. Malek; Brian J-F. Wong; Justus F. R. Ilgner; Kenton W. Gregory; Guillermo J. Tearney; Laura Marcu; Henry Hirschberg; Steen J. Madsen, Eds.): Proceedings Photonics West 2009: Photonic Therapeutics and Diagnostics V, SPIE 7161(71612Y):1-10, 2009.

  • Kim K, Dean D, Mikos AG, Fisher JP: Effect of Initial Cell Seeding Density on Early Osteogenic Signal Expression of Rat Bone Marrow Stromal Cells Cultured on Cross-Linked Poly(propylene fumarate) Disks. Biomacromolecules. 10:1810-1817, 2009.

  • Hu X, Maciunas RJ, Dean D: A new Gamma Knife radiosurgery paradigm: tomosurgery. Med Phys 34:1743-1758, 2007.

  • Zhang L, Dean D, Liu JZ, Sahgal V, Wang X, Yue GH: Quantifying degeneration of white matter in normal aging using fractal dimension. Neurobiol Aging 28:1543-1555, 2007.

  • Varghai D, Covey K, Sharma R, Cross N, Feyes DK, Oleinick NL, Flask CA, Dean D: Monitoring Pc 4-mediated Photodynamic Therapy of U87 Tumors with Dynamic Contrast Enhanced-Magnetic Resonance Imaging (DCE-MRI) in the Athymic Nude Rat. Photonics West 2008: In (Nikiforos Kollias; Bernard Choi; Haishan Zeng; Reza S. Malek; Brian J. Wong; Justus F. R. Ilgner; Kenton W. Gregory; Guillermo J. Tearney; Henry Hirschberg; Steen J. Madsen, Eds.): Proceedings Photonics West 2008: Photonic Therapeutics and Diagnostics IV, SPIE 6842(68422P):1-9, 2008.

  • Cross N, Sharma R, Varghai D, Spring-Robinson C, Oleinick NL, Muzic RF Jr., Dean D: Hardware, Software, and Scanning Issues Encountered during Small Animal Imaging of Photodynamic Therapy in the Athymic Nude Rat. In (Nikiforos Kollias; Bernard Choi; Haishan Zeng; Reza S. Malek; Brian J. Wong; Justus F. R. Ilgner; Kenton W. Gregory; Guillermo J. Tearney; Henry Hirschberg; Steen J. Madsen, Eds.): Proceedings Photonics West 2007: Photonic Therapeutics and Diagnostics III, SPIE 6424(64242K):1-7, 2007.

  • Cross N, Varghai D, Spring-Robinson C, Sharma R, Muzic RF Jr., N. L. Oleinick, D. Dean: Analysis of 18F-fluorodeoxy-glucose PET imaging data captured before and after Pc 4-mediated photodynamic therapy of U87 tumors in the athymic nude rat. In (Nikiforos Kollias; Bernard Choi; Haishan Zeng; Reza S. Malek; Brian J. Wong; Justus F. R. Ilgner; Kenton W. Gregory; Guillermo J. Tearney; Henry Hirschberg; Steen J. Madsen, Eds.): Proceedings Photonics West 2007: Photonic Therapeutics and Diagnostics III, SPIE 6424(64242F):1-8, 2007.

  • Varghai D, Cross N, Spring-Robinson C, Sharma R, Feyes DK, Ahmad Y, Oleinick NL, Muzic RF Jr., Dean D: Monitoring Pc 4-mediated photodynamic therapy of U87 tumors with F18-fluorodeoxy-glucose PET imaging in the athymic nude rat. In (Nikiforos Kollias; Bernard Choi; Haishan Zeng; Reza S. Malek; Brian J. Wong; Justus F. R. Ilgner; Kenton W. VIII Gregory; Guillermo J. Tearney; Henry Hirschberg; Steen J. Madsen, Eds.): Proceedings Photonics West 2007: Photonic Therapeutics and Diagnostics III, SPIE 6424(64242G):1-7, 2007.

  • Varghai D, Azizuddin K, Ahmad Y, Feyes DK, Oleinick NL, Dean D: Fluorescence of Pc 4 in U87 Cells Following Photodynamic Therapy. In (Nikiforos Kollias; Bernard Choi; Haishan Zeng; Reza S. Malek; Brian J. Wong; Justus F. R. Ilgner; Kenton W. Gregory; Guillermo J. Tearney; Henry Hirschberg; Steen J. Madsen, Eds.): Proceedings Photonics West 2007: Photonic Therapeutics and Diagnostics III, SPIE 6424(64242A):1-6, 2007.

  • George JE, Ahmad Y, Varghai D, Li X, Berlin J, Jackowe D, Jungermann M, Wolfe MS, Lilge L, Totonchi A, Morris RL, Peterson A, Lust WD, Kenney ME, Hoppel CL, Sun J, Oleinick NL, Dean D. Pc 4 photodynamic therapy of U87-derived human glioma in the nude rat. Las Surg Med 36:383-389, 2005.

  • Dean D, Wolfe MS, Ahmad Y, Totonchi A, Chen JE-K, Fisher JP, Cooke MN, Rimnac CM, Lennon DP, Caplan AI, Topham NS, Mikos AG. Effect of Transforming Growth Factor b2 on Marrow-Infused Foam Poly(Propylene Fumarate) Tissue-Engineered Constructs for the Repair of Critical-Size Cranial Defects in Rabbits. Tissue Engineering 11:923-939, 2005.

  • Dean D, George JE, Ahmad Y, Wolfe MS, Lilge L, Morris RL, Peterson A, Lust WD, Totonchi A, Varghai D, Li X, Hoppel CL, Sun J, Oleinick NL. Pc 4 photodynamic therapy of U87 (human glioma) orthotopic tumor in nude rat brain. In (Bartels, Bass, de Riese, Gregory, Hirschberg, Katzir, Kollias, Madsen, Malek, McNally-Heintzelman, Tate, Trowers, Wong, eds.): Photonic Therapeutics and Diagnostics, Proc. Of BiOS 2005, San Jose, CA, SPIE 5686:526-542, 2005.

  • Contact Information
    Department of Neurological Surgery
    Case Western Reserve University
    10900 Euclid Avenue, HH5, MS 5042
    Cleveland, OH 44106 USA
    Telephone: (216) 844-3333
    Fax: (216) 844-3336
    E-mail: David.Dean@Case.Edu