David Dean, Ph.D.
Profile
David Dean received his Ph.D.
in Biological Anthropology at the City University of New York
in 1993. He completed a post-doctoral fellowship in the Institute of Reconstructive Plastic
Surgery in 1994 at the New York University School of Medicine before joining the faculty of the School of Medicine at Case Western Reserve University in Cleveland.
He directs the Department of Neurological Surgery Imaging
Laboratory. His research interests are in Computer-Assisted
Surgery, skull (bone) tissue engineering, photodynamic therapy
of glioma, and automated radiosurgery treatment
planning.
Contact Information
Department of Neurological
Surgery
Case Western Reserve
University
10900 Euclid Avenue, HH5, MS 5042
Cleveland, OH 44106 USA
Telephone: (216) 844-3333
Fax: (216) 844-3336
E-mail: David.Dean@Case.Edu
Vistors and Deliveries
Wearn Bldg., Room 352
2058 Abington Road
Cleveland, OH 44106 USA
Recent Publications
Kim K, Dean D, Wallace J, Breithaupt R, Mikos AG, Fisher JP. The influence of stereolithographic scaffold architecture and composition on osteogenic signal expression with rat bone marrow stromal cells. Biomaterials 32(15):3750-3763, 2011.
Kim K, Dean D, Lu A, Mikos AG, Fisher JP: Early osteogenic signal expression of rat bone marrow stromal cells is influenced by both hydroxyapatite nanoparticle content and initial cell seeding density in biodegradable nanocomposite scaffolds. Acta Biomater. 7:1249-1264, 2011
Song MJ, Dean D, Knothe Tate ML: In situ spatiotemporal mapping of flow fields around seeded stem cells at the subcellular length scale. PLoS One. 5: pii: e12796, 2010.
Kim K, Yeatts A, Dean D, Fisher JP: Stereolithographic Bone Scaffold Design Parameters: Osteogenic Differentiation and Signal Expression. Tissue Eng Part B Rev. 16:523-539, 2010.
Anka A, Thompson P, Mott E, Sharma R, Zhang R, Cross N, Sun J, Flask CA, Oleinick NL, Dean D: Dynamic Contrast Enhanced-Magnetic Resonance Imaging (DCE-MRI) for the Assessment of Pc 4-Sensitized Photodynamic Therapy of a U87-derived Glioma Model in the Athymic Nude Rat. SPIE, Proceedings Photonics West 2010: Photonic Therapeutics and Diagnostics VI, 7548(75483X):1-8, 2010.
Dean D, Wallace J, Kim K, Mikos AG, Fisher JP: Stereolithographic Rendering of Low Molecular Weight Polymer Scaffolds for Bone Tissue Engineering. In (Paulo Jorge da Silva Bártolo; Ana Cristina Soares de Lemos ; António Marió Henriques Pereira; Artur Jorge dos Santos Mateus; Ausenda Luís Avelar Mendes; Carla Sofia Monteiro de Moura; Carlos Alexandre Bento Capela; Catarina Sofia Gaspar da Silva; Flávio André Carvalho Domingues; Helena Maria Coelho da Rocha Terreiro Galha Bártolo; Henrique de Amorim Almeida; Irene Sofia Carvalho Ferreira; Joăo Manuel Matias; Nuno Manuel Fernandes Alves; Susana Cristina Serrano Fernandes Rodrigues): Proceedings of the 4th International Conference on Advanced Research and Rapid Prototyping, Leiria, Portugal, 6-10 October 2009: "Innovative Developments in Design and Manufacturing: Advanced research in virtual and rapid prototyping", CRC Press (Taylor & Francis), Boca Raton, FL, pp. 37-43, 2010.
Cross N, Varghai D, Flask CA, Feyes DK, Oleinick NL, Dean D: Optimal Gadolinium Dose Level for Magnetic Resonance Imaging (MRI) Contrast Enhancement of U87-derived Tumors in Athymic Nude Rats for the Assessment of Photodynamic Therapy. In (Nikiforos Kollias; Bernard Choi; Haishan Zeng; Reza S. Malek; Brian J-F. Wong; Justus F. R. Ilgner; Kenton W. Gregory; Guillermo J. Tearney; Laura Marcu; Henry Hirschberg; Steen J. Madsen, Eds.): Proceedings Photonics West 2009: Photonic Therapeutics and Diagnostics V, SPIE 7161(71612Y):1-10, 2009.
Kim K, Dean D, Mikos AG, Fisher JP: Effect of Initial Cell Seeding Density on Early Osteogenic Signal Expression of Rat Bone Marrow Stromal Cells Cultured on Cross-Linked Poly(propylene fumarate) Disks. Biomacromolecules. 10:1810-1817, 2009.
Hu X, Maciunas RJ, Dean D: A new Gamma Knife radiosurgery paradigm: tomosurgery. Med Phys 34:1743-1758, 2007.
Zhang L, Dean D, Liu JZ, Sahgal V, Wang X, Yue GH: Quantifying degeneration of white matter in normal aging using fractal dimension. Neurobiol Aging 28:1543-1555, 2007.
Varghai D, Covey K, Sharma R, Cross N, Feyes DK, Oleinick NL, Flask CA, Dean D: Monitoring Pc 4-mediated Photodynamic Therapy of U87 Tumors with Dynamic Contrast Enhanced-Magnetic Resonance Imaging (DCE-MRI) in the Athymic Nude Rat. Photonics West 2008: In (Nikiforos Kollias; Bernard Choi; Haishan Zeng; Reza S. Malek; Brian J. Wong; Justus F. R. Ilgner; Kenton W. Gregory; Guillermo J. Tearney; Henry Hirschberg; Steen J. Madsen, Eds.): Proceedings Photonics West 2008: Photonic Therapeutics and Diagnostics IV, SPIE 6842(68422P):1-9, 2008.
Cross N, Sharma R, Varghai D, Spring-Robinson C, Oleinick NL, Muzic RF Jr., Dean D: Hardware, Software, and Scanning Issues Encountered during Small Animal Imaging of Photodynamic Therapy in the Athymic Nude Rat. In (Nikiforos Kollias; Bernard Choi; Haishan Zeng; Reza S. Malek; Brian J. Wong; Justus F. R. Ilgner; Kenton W. Gregory; Guillermo J. Tearney; Henry Hirschberg; Steen J. Madsen, Eds.): Proceedings Photonics West 2007: Photonic Therapeutics and Diagnostics III, SPIE 6424(64242K):1-7, 2007.
Cross N, Varghai D, Spring-Robinson C, Sharma R, Muzic RF Jr., N. L. Oleinick, D. Dean: Analysis of 18F-fluorodeoxy-glucose PET imaging data captured before and after Pc 4-mediated photodynamic therapy of U87 tumors in the athymic nude rat. In (Nikiforos Kollias; Bernard Choi; Haishan Zeng; Reza S. Malek; Brian J. Wong; Justus F. R. Ilgner; Kenton W. Gregory; Guillermo J. Tearney; Henry Hirschberg; Steen J. Madsen, Eds.): Proceedings Photonics West 2007: Photonic Therapeutics and Diagnostics III, SPIE 6424(64242F):1-8, 2007.
Varghai D, Cross N, Spring-Robinson C, Sharma R, Feyes DK, Ahmad Y, Oleinick NL, Muzic RF Jr., Dean D: Monitoring Pc 4-mediated photodynamic therapy of U87 tumors with F18-fluorodeoxy-glucose PET imaging in the athymic nude rat. In (Nikiforos Kollias; Bernard Choi; Haishan Zeng; Reza S. Malek; Brian J. Wong; Justus F. R. Ilgner; Kenton W. VIII Gregory; Guillermo J. Tearney; Henry Hirschberg; Steen J. Madsen, Eds.): Proceedings Photonics West 2007: Photonic Therapeutics and Diagnostics III, SPIE 6424(64242G):1-7, 2007.
Varghai D, Azizuddin K, Ahmad Y, Feyes DK, Oleinick NL, Dean D: Fluorescence of Pc 4 in U87 Cells Following Photodynamic Therapy. In (Nikiforos Kollias; Bernard Choi; Haishan Zeng; Reza S. Malek; Brian J. Wong; Justus F. R. Ilgner; Kenton W. Gregory; Guillermo J. Tearney; Henry Hirschberg; Steen J. Madsen, Eds.): Proceedings Photonics West 2007: Photonic Therapeutics and Diagnostics III, SPIE 6424(64242A):1-6, 2007.
Zhang L, Liu JZ, Dean D, Sahgal V, Yue GH: A Three-dimensional fractal analysis method for quantifying white matter structure in human brain. Journal Neurosci Methods 150:242-253, 2006.
George JE, Ahmad Y, Varghai D, Li X, Berlin J, Jackowe D, Jungermann M, Wolfe MS, Lilge L, Totonchi A, Morris RL, Peterson A, Lust WD, Kenney ME, Hoppel CL, Sun J, Oleinick NL, Dean D. Pc 4 photodynamic therapy of U87-derived human glioma in the nude rat. Las Surg Med 36:383-389, 2005.
Dean D, Wolfe MS, Ahmad Y, Totonchi A, Chen JE-K, Fisher JP, Cooke MN, Rimnac CM, Lennon DP, Caplan AI, Topham NS, Mikos AG. Effect of Transforming Growth Factor b2 on Marrow-Infused Foam Poly(Propylene Fumarate) Tissue-Engineered Constructs for the Repair of Critical-Size Cranial Defects in Rabbits. Tissue Engineering 11:923-939, 2005.
Dean D, George JE, Ahmad Y, Wolfe MS, Lilge L, Morris RL, Peterson A, Lust WD, Totonchi A, Varghai D, Li X, Hoppel CL, Sun J, Oleinick NL. Pc 4 photodynamic therapy of U87 (human glioma) orthotopic tumor in nude rat brain. In (Bartels, Bass, de Riese, Gregory, Hirschberg, Katzir, Kollias, Madsen, Malek, McNally-Heintzelman, Tate, Trowers, Wong, eds.): Photonic Therapeutics and Diagnostics, Proc. Of BiOS 2005, San Jose, CA, SPIE 5686:526-542, 2005.
Varghai D, Azizuddin K, Ahmad Y, Feyes DK, Oleinick NL, Dean D. Fluorescence of Pc 4 in U87 Cells Following Photodynamic Therapy. In (Nikiforos Kollias; Bernard Choi; Haishan Zeng; Reza S. Malek; Brian J. Wong; Justus F. R.Ilgner; Kenton W. Gregory; Guillermo J. Tearney; Henry Hirschberg; Steen J. Madsen, Eds.): Proceedings Photonics West 2007: Photonic Therapeutics and Diagnostics III, SPIE 6424:64242A1-64242A6.
Varghai D, Cross N, Spring-Robinson C, Sharma R, Feyes DK, Ahmad Y, Oleinick NL, Muzic RF Jr., Dean D. Monitoring Pc 4-mediated photodynamic therapy of U87 tumors with F18-fluorodeoxy-glucose PET imaging in the athymic nude rat. In (Nikiforos Kollias; Bernard Choi; Haishan Zeng; Reza S. Malek; Brian J. Wong; Justus F. R.Ilgner; Kenton W. Gregory; Guillermo J. Tearney; Henry Hirschberg; Steen J. Madsen, Eds.): Proceedings Photonics West 2007: Photonic Therapeutics and Diagnostics III, SPIE 6424:64242G1-64242G7.
Cross N, Varghai D, Spring-Robinson C, Sharma R, Muzic RF Jr., N. L. Oleinick, D. Dean. Analysis of 18F-fluorodeoxy-glucose PET imaging data captured before and after Pc 4-mediated photodynamic therapy of U87 tumors in the athymic nude rat. In (Nikiforos Kollias; Bernard Choi; Haishan Zeng; Reza S. Malek; Brian J. Wong; Justus F. R.Ilgner; Kenton W. Gregory; Guillermo J. Tearney; Henry Hirschberg; Steen J. Madsen, Eds.): Proceedings Photonics West 2007: Photonic Therapeutics and Diagnostics III, SPIE 6424:64242F1-64242F8.
Cross N, Sharma R, Varghai D, Spring-Robinson C, Oleinick NL, Muzic RF Jr., Dean D. Hardware, Software, and Scanning Issues Encountered during Small Animal Imaging of Photodynamic Therapy in the Athymic Nude Rat. In (Nikiforos Kollias; Bernard Choi; Haishan Zeng; Reza S. Malek; Brian J. Wong; Justus F. R.Ilgner; Kenton W. Gregory; Guillermo J. Tearney; Henry Hirschberg; Steen J. Madsen, Eds.): Proceedings Photonics West 2007: Photonic Therapeutics and Diagnostics III, SPIE 6424:64242K1-64242K7.
Hu X, Maciunas RJ, Dean D. A new Gamma Knife radiosurgery paradigm: tomosurgery. Med Phys 34:1743-1758, 2007.
Varghai D, Covey K, Sharma R, Cross N, Feyes DK, Oleinick NL, Flask CA, Dean D. Monitoring Pc 4-mediated Photodynamic Therapy of U87 Tumors with Dynamic Contrast Enhanced-Magnetic Resonance Imaging (DCE-MRI) in the Athymic Nude Rat. Proceedings Photonics West 2008: Photonic Therapeutics and Diagnostics, SPIE 6842E (in press).
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