Our Work
Brain Aging and Biological
Diversity
The Laboratory of Neurogeriatrics
is dedicated to enhancing our understanding of
age-related brain disorders, especially Alzheimer's
disease, through a diversity of biological
approaches to disease mechanisms in living patients.
We use studies of populations of individuals
(epidemiology), as well as investigations of
pathophysiology involving analyses of blood,
cerebrospinal fluid, genes, and cerebral blood flow,
metabolism and blood-brain barrier permeability in
patients and controls.
Current
funded research
activities of the laboratory include:
-
Family studies of
genetic and environmental risk and protective
factors for Alzheimer's disease
-
MIRAGE project
-
Genetics of
Alzheimer's disease in Israeli Arabs
-
Symposium on
Alzheimer's disease in the Middle East
-
Cholesterol
feeding and cerebral a-beta deposition in dogs
-
Retinal
photography in dementia
-
Longitudinal studies
of the interactions of brain aging and
cardiovascular diseases
-
African American
Health Literacy Program
Past funded research
activities of the laboratory included:
-
Alzheimer Center Case-Control
Study
-
Genetics of Alzheimer's
disease in Israeli Arabs
-
A population based prevalence
study of genetic and environmental factors for
Alzheimer's disease in Kenya
-
Non-invasive imaging and
cerebral amyloid beta deposition in Alzheimer's
disease
-
The effects of nicotine on
amyloid beta protein aggregation (Principal
investigator Michael Zagorski, PhD, Department of
Chemistry, CWRU)
-
Noninvasive Assessment of
Oxidative Stress in Patients with Alzheimer's
Disease (Principal Investigator, G. Perry)
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