We
are screening 3,000 people over the age of 65 (using
random selection) in the Nyeri District in central
Kenya for studies of the prevalence of Alzheimer's
disease and
evaluation of risks and protective factors, with
particular attention to apolipoprotein E genotypes.
We will detect genetic and environmental factors
which may be responsible for the reduced prevalence
of the disease in Black Africans and for the lack of
risk factor effect of the apolipoprotein E4 genotype
in Africans.