Charles S. Britton II Professor of Hematology and Oncology, Case
Education:
M.D. - 1971 - Ohio State University, Summa Cum Laude
B.A. - 1968 - Ohio State University, Summa Cum Laude
Certifications:
1976 - American Board of Internal Medicine
1978 - American Board of Internal Medicine, Subspecialty of Hematology
Professional Training:
1971–72 - Internship in Medicine, Yale-New Haven Medical Center,
New Haven, Connecticut
1972–73 - Assistant Resident in Medicine, Barnes Hospital,
Washington University School of Medicine, St. Louis
1975–76 - Clinical Fellow in Hematology/Oncology, Barnes Hospital,
Washington University School of Medicine, St. Louis, Missouri
1976–78 - Research Fellow in Hematology/Oncology, Laboratory of Dr. John C. Rogers, Washington University School of Medicine, St. Louis, Missouri
2003 - Visiting Scientist under Professors Sir Michael Berridge and Martin Bootman, Calcium Group, Laboratory of Molecular Signaling, Babraham Institute, Cambridge, UK
Research Interests:
Mechanism of apoptosis induction by glucocorticosteroid hormones, and mechanism of Bcl-2 family action. Role of stress proteins in apoptosis regulation.
Current Research Support:
1. Mechanism of Glucocorticoid Action in Lymphoid Malignancy
NIH R01 CA42755-16
Clark W. Distelhorst, M.D., P.I. 30% salary/effort
11/01/85–11/30/04 $188,396 (annual direct costs)
2. Stress responses and apoptosis
NIH RO1CA79806-04
Clark W. Distelhorst, M.D., P.I. 25% salary/effort
1/1/99-12/31/04 $149,175 (annual direct) $1,038,144 (total direct)
3. Bcl-2 function in the endoplasmic reticulum
NIH RO1 CA85804-02
Clark W. Distelhorst, M.D., P.I.20% salary/effort
4/1/00 - 3/31/05 $157,500 (annual direct costs)
4. Research Oncology Training Grant
NIH/NCI T32 CA59366-10
Clark W. Distelhorst, M.D., P.I. 5% (no salary)
06/01/93–05/31/03 $307,201 (annual direct costs)
5. International Union Against Cancer Travel Award, $19,600
Clark W. Distelhorst, MD, PI
Publications:
1. He H, Distelhorst CW. Involvement of c-Fos in signaling grp78 induction following ER calcium release. Oncogene 19:5936-5943, 2000.
2. Unkila M, McColl KS, Thomenius MJ, Heiskanen K, Distelhorst CW. Unreliability of cytochrome c-EGFP fusion protein as a marker of cytochrome c release in cells that overexpress Bcl-2. J. Biol. Chem. 276:39132-39137, 2001
3. Wang NS, Unkila MT, Reineks EZ, Distelhorst CW. Transient expression of wild-type or mitochondrially targeted Bcl-2 induces apoptosis while transient expression of ER-targeted Bcl-2 is protective against Bax induced cell death. J. Biol. Chem. 276:44117-44128, 2001
4. Thomenius MJ, Wang NS, Reineks EZ, Wang Z, and Distelhorst CW. Bcl-2 on the endoplasmic reticulum regulates Bax activity by binding to BH3 only proteins. J. Biol. Chem. 278:6243-6250, 2003
5. Wang Z, Malone MH, He H, McColl KS, Distelhorst CW. Microarray analysis uncovers the induction of the pro-apoptotic BH3-only protein Bim in multiple models of glucocorticoid induced apoptosis. J. Biol. Chem. 278:23861-23867, 2003
6. Wang Z, Malone MH, Thomenius MJ, Zhong F, Xu F, Distelhorst CW. Dexamethasone-induced gene 2 (dig2) is a novel prosurvival stress gene induced rapidly by diverse apoptotic signals. J Biol Chem 278:27053-27058, 2003
7. Chen, R., Zhong, F., McColl, K.S., Roderick, H.L., Bootman, M.D., Berridge, M.J., Conway, S.J., Holmes, A.B., Distelhorst, C.W. Bcl-2 interacts with inositol 1,4,5-trisphosphate receptors and inhibits inositol 1,4,5-trisphosphate-mediated calcium release from the endoplasmic reticulum. (Submitted for publication)
Publications (Chapters and Review Articles):
1. Distelhorst, CW. Recent insights into the mechanism of glucocorticosteroid-induced apoptosis of lymphoid cells Cell Death and Differentiation 9:6-19. 2002
3. Distelhorst CW, Roderick, HL. Ins(1,4,5)P3-mediated calcium signals and apoptosis: is there a role for Bcl-2? Biochemical Society Transactions 31:958-959, 2003.
4. Thomenius MJ and Distelhorst CW. Bcl-2 on the endoplasmic reticulum: Protecting mitochondria from a distance. J Cell Science 116:4493-4499, 2003.
5. Distelhorst, C.W. and Shore, G. Bcl-2 and calcium: Controversey beneath the surface. (invited review for Oncogene, submitted).
Abstracts:
1. He, H, Distelhorst, CW. C-Fos is required for GRP78 (BiP) induction following ER calcium release. Presented at the Keystone Symposium Signaling 2000, January 22-28, 2000, Keystone, CO.
2. Wang, NS, Reineks, EZ, Distelhorst, CW. Induction of apoptosis by Bcl-2 and its dependence on subcellular localization. Presented at Mechanisms of Cell Death 2000. 3 rd Symposium of the International Cell Death Society. El Escorial Monastery,May 6-10, 2000.
3. Wang, NS, Reineks, EZ, Distelhorst, CW. Proapoptotic and antiapoptotic activities of Bcl-2 depend on subcellular localization. Presented at Keystone Symposium on Molecular Mechanisms of Apoptosis, Keystone, CO, January 16-22, 2001
4. He, H, Malone, M, Ostrowshi, S, Distelhorst, C. Gene expression analysis of glucocorticoid-induced apoptosis by gene microarray technique. Presented at AACR/Nature Genetics Conference: Oncogenomics, Dissecting Cancer Through Genome Research. Tucson, AZ, January 25-28, 2001
Department of Medicine|
11100 Euclid Avenue| Cleveland, Ohio 44106
