Publications
Lai N, Zhou H, Saidel GM, Wolf M, McCully K, Gladden LB, Cabrera ME. Modeling oxygenation in venous blood and skeletal muscle in response to exercise using near-infrared spectroscopy. J Appl Physiol. 106(6):1858-74, 2009.
Zhou H, Lai N, Saidel GM, Cabrera ME. Multi-scale modeling of respiration: linking external to cellular respiration during exercise. IEEE Engineering in Medicine and Biology 28(3):34-40, 2009.
Li Y, Dash RK, Kim J, Saidel GM, Cabrera ME. Role of NADH/NAD+ transport activity and glycogen store on skeletal muscle energy metabolism during exercise: in silico studies. Am J Physiol Cell Physiol, 296(1):C25-46, 2009.
Dash RK, Li Y, Kim J, Beard DA, Saidel GM, Cabrera ME. Metabolic dynamics in skeletal muscle during acute reduction in blood flow and oxygen supply to mitochondria: in-silico studies using a multi-scale, top-down integrated model. PLoS One. 9;3(9):e3168, 2008.
Beard DA, Wu F, Cabrera ME, Dash RK. Modeling of cellular metabolism and microcirculatory transport. Microcirculation. 15(8):777-93, 2008.
Lu M, Zhou L, Stanley WC, Cabrera ME, Saidel GM, Yu X. Role of the malate-aspartate shuttle on the metabolic response to myocardial ischemia. J Theor Biol. 21;254(2):466-75, 2008.
Lai N., Nasca M., Silva M.A., Silva F.T., Whipp B.J. and Cabrera M.E., Influence of exercise intensity on pulmonary oxygen uptake kinetics at the onset of exercise and recovery in male adolescents Appl. Physiol. Nutr. Metab. 33(1): 107-117 (2008).
Dash RK, Li Y, Kim J, Saidel GM, Cabrera ME. Modeling cellular metabolism and energetics in skeletal muscle: large-scale parameter estimation and sensitivity analysis. IEEE Trans Biomed Eng. 55(4):1298-318, 2008.
Hakimi P, Yang J, Casadesus G, Massillon D, Tolentino-Silva F, Nye CK, Cabrera ME, Hagen DR, Utter CB, Baghdy Y, Johnson DH, Wilson DL, Kirwan JP, Kalhan SC, Hanson RW. Over-expression of the cytosolic form of phosphoenolpyruvate carboxykinase (GTP) in skeletal muscle repatterns energy metabolism in the mouse. J. Biol. Chem. 282:32844-55, 2007.
Dash RK, DiBella JA, Cabrera ME. A computational model of skeletal muscle metabolism linking cellular adaptations induced by altered loading states to metabolic responses during exercise. Biomed Eng Online Apr 20; 6(1):14, 2007.
Lai N, Saidel GM, Grassi B, Gladden LB, and Cabrera ME Model of O2 transport and metabolism predicts effect of hyperoxia on canine muscle oxygen uptake dynamics. J. Appl. Physiol. 103:1366-78, 2007.
Lai N, Camesasca M, Saidel GM, Dash RK, Cabrera ME. Linking pulmonary oxygen uptake, muscle oxygen utilization and cellular metabolism during exercise. Ann Biomed Eng. 35(6): 956-968, 2007.
Dash RK, Somersalo E, Cabrera ME, Calvetti D. An efficient deconvolution algorithm for estimating oxygen consumption during muscle activities. Comput Methods Programs Biomed. 85:247-256, 2007.
Zhou H, Saidel GM, and Cabrera ME. Multi-organ system model of O2 and CO2 transport during isocapnic and poikilocapnic hypoxia. Respir Physiol Neurobiol. 156:320-30, 2007.
Zhou L, Cabrera ME, Huang H, Yuan CL, Monika DK, Sharma N, Bian F. and Stanley WC. Parallel activation of mitochondrial oxidative metabolism with increased cardiac energy expenditure is not dependent on fatty acid oxidation in pigs. J Physiol 579:811-821, 2007.
Kim J, Saidel GM, and Cabrera ME. Multi-scale computational model of fuel homeostasis during exercise: effect of hormonal control. Ann Biomed Eng. 35:69-90, 2007.
Landesberg A, Shenhav A, Shofty R, Konyukhov E, Levy C, Lichtenstein O, Beyar R, Ter Keurs HEDJ, Landesberg G, Cabrera ME, Stanley WC, and Saidel GM. Effects of synchronized cardiac assist device on cardiac energetics. Ann. N. Y. Acad. Sci. 1080:466-478, 2006.
Zhou L, Yu X, Cabrera ME and Stanley WC. Role of cellular compartmentation in the metabolic response to stress. Mechanistic insights from computational models, Ann. N. Y. Acad. Sci. 1080:120-139, 2006.
Lai N, Dash RK, Nasca MM, Saidel GM, and Cabrera ME. Relating pulmonary oxygen uptake to muscle oxygen consumption at exercise onset: in vivo and in silico studies. Eur J Appl Physiol 97:380-94, 2006.
Zhou L, Cabrera ME, Okere IC, Sharma N, and Stanley WC. Regulation of myocardial substrate metabolism during increased energy expenditure: Insights from computational studies, Am J Physiol Heart Circ Physiol 291:H1036-H1046, 2006.
Bederman IR, Dufner DA, Alexander JC and Previs SF. Novel application of the "doubly labeled" water method: measuring CO2 production and the tissue-specific dynamics of lipid and protein in vivo. Am J Physiol Endocrinol Metab 290: E1048-E1056, 2006.
McCabe BJ, Bederman IR, Croniger C, Millward C, Norment C and Previs SF. Reproducibility of gas chromatography-mass spectrometry measurements of 2H labeling of water: application for measuring body composition in mice. Anal Biochem 350: 171-176, 2006.
Melanson KJ, TJ. Angelopoulos TJ, Nguyen VT, Zukley L, Lowndes J, Dube TJ, Fiutem JJ, Yount BW, Rippe JM. Consumption of Whole Grain Cereals During Weight Loss: Effects on Dietary Quality. Journal of American Dietetic Association, Press 106(9):1380-82006.
Paridon SM, Alpert BS, Boas SR, Cabrera ME, Caldarera LL, Daniels SR, Kimball TR, Knilans TK, Nixon PA, Rhodes J, Yetman AT; American Heart Association Council on Cardiovascular Disease in the Young, Committee on Atherosclerosis, Hypertension, and Obesity in Youth: Clinical stress testing in the pediatric age group: a statement from the American Heart Association Council on Cardiovascular Disease in the Young, Committee on Atherosclerosis, Hypertension, and Obesity in Youth. Circulation 113(15):1905-20, 2006.
Calvetti D, Dash RK, Somersalo E, and Cabrera ME. Local regularization method applied to estimating oxygen consumption during muscle activities. Inverse Problems, 22:229-243, 2006.
Zhou L, Stanley WC, Saidel GM, Yu X, and Cabrera ME. Regulation of lactate production at the onset of ischemia is independent of mitochondrial NADH/NAD+: Insights from in silico studies. Journal of Physiology, 569(Pt 3):925-37, 2005. # Cabrera ME, Zhou L, Stanley WC, and Saidel GM. Regulation of Cardiac Energetics: Role of redox state and cellular compartmentation during ischemia. Ann. N.Y. Acad. Sci., 1047:259-270, 2005.
Dufner DA, Bederman IR, Brunengraber DZ, Rachdaoui N, Ismail-Beigi F, Siegfried BA, Kimball SR and Previs SF. Using 2H2O to study the influence of feeding on protein synthesis: effect of isotope equilibration in vivo vs. in cell culture. Am J Physiol Endocrinol Metab 288: E1277-E1283, 2005.
Grossner CM, Johnson EM, and Cabrera ME. Efficiency and economy in female adolescents and adults matched for height and weight. Ped. Exer. Sci., 17:301-310, 2005.
Zhou L, Salem JE, Saidel GM, Stanley WC, Cabrera ME. Mechanistic model of cardiac energy metabolism predicts localization of glycolysis to cytosolic sub-domain during ischemia. Am. J. Physiol. Heart Circ. Physiol., 288(5):H2400-11, 2005.
Salem JE, Cabrera ME, Chandler MP, McElfresh TA, Huang H, Sterk JP, and Stanley WC. Step and ramp induction of myocardial ischemia: comparison of in vivo and in silico results. J. of Physiol. & Pharmacol. 55:519-536, 2004.
Salem JE, Stanley WC, and Cabrera ME. Computational studies of the effects of myocardial blood flow reduction on cardiac metabolism. Biomedical Engineering Online 3(1):15, 2004.
Grossner CM, Johnson EM, and Cabrera ME. Effect of high-intensity training on exercise performance of pre-adolescent female soccer players. Rev. Portuguesa de Ciencias do Desporto 3(2):79-82, 2003.
Radhakrishnan K, LaManna JC, Cabrera ME. A quantitative study of oxygen as a metabolic regulator. Adv. Exp. Med. Biol., 530:547-54, 2003.
DiBella II JA, Johnson EM, and Cabrera ME. Ramped vs. Standard Bruce protocol in children. A comparison of exercise responses. Ped. Exerc. Sci. 14(4):391-400, 2002.
Soller BR, Cabrera ME, Smith SM, and Sutton JP. Smart medical systems with application to nutrition and fitness in space. Nutrition 18:930-936, 2002.
Cabrera ME, Portzline G, Aach SE, Condie C, Dorostkar P, Mianulli M. Can current minute ventilation rate adaptive pacemakers provide appropriate chronotropic response in pediatric patients? Pacing and Clinical Electrophysiology 25:907-914, 2002.
Salem JE, Saidel GM, Stanley WC, and Cabrera ME. Mechanistic model of myocardial energy metabolism under normal and ischemic conditions. Ann. Biomed. Eng. 30:202-216, 2002.
Radhakrishnan K, LaManna JC, and Cabrera ME. A quantitative study of oxygen as a metabolic regulator. Applied Cardiopulmonary Pathophysiology. 9:363-367, 2000. # Cabrera ME, Saidel GM, and Kalhan SC. A model analysis of lactate accumulation during muscle ischemia. J. Crit. Care. 14:151-163, 1999.
Cabrera ME, Saidel GM, and Kalhan SC. Lactate metabolism during exercise. Analysis by an integrative systems model. Am. J. Physiol. 277:R1522-R1536, 1999.
Cabrera ME, Saidel GM, and Kalhan SC. Modeling metabolic dynamics. From cellular processes to organ and whole body responses. Prog. Biophysics & Molecular Biology, 69:539-557, 1998.
Cabrera ME, Saidel GM, and Kalhan SC. Role of oxygen in regulation of lactate dynamics during hypoxia: mathematical model and analysis. Ann. Biomed. Eng. 26:1-27, 1998.
Cabrera ME and Chizeck HJ. On the existence of a lactate threshold during incremental exercise; A systems engineering approach. J. Appl. Physiol. 80:1819-1828, 1996.
Cabrera ME, Lough MD, Doershuk CF, Salvator A. An expanded scoring system including an index of nutritional status for patients with cystic fibrosis. Pediatr. Pulmonol. 18:199 205, 1994.
Cabrera ME, Hanisch DG, Cohen MH, Spector ML and Liebman J. Cardiopulmonary responses to exercise in children with activity sensing rate responsive ventricular pacemakers. Pacing and Clinical Electrophysiology 16:1386 93, 1993.
Cabrera ME, Lough MD, Doershuk CF, DeRivera GA. Anaerobic performance assessed by the Wingate Test in patients with cystic fibrosis. Pediatric Exercise Science 5:78 87, 1993.
Cabrera ME, Saidel GM, and Cohen MH. Noninvasive estimation of cardiac output with nonprescribed breathing. Annals of Biomedical Engineering, 19:723 742, 1991.