Biochemical Toxicology II
EVHS 402B
 
Spring 1998
Thursdays, 5:15-6:30 PM
Medical School, WG-23
 
Lecturers:
G. David McCoy, PhD [368-5963] Rm. WG-19
Ellen A. Rorke, PhD [368-5411] Rm. WG-19
Hasan Mukhtar, PhD [368-1127] Rm. SOM BRB #521

Referenced Texts:

H&L: E. Hodgson & P. Levi (Eds.), A Textbook of Modern Toxicology, Elsevier Press, 1997(2nd ed), 496 pp.
P&T: W.B. Pratt & P. Taylor (Eds.), Principles of Drug Action: Third Edition, Churchill Livingstone Publishers, 1990, 836 pp.

Topics to Be Covered:

Week Lecture Lecturer Reference
I Organizational McCoy H&L,pp 1-24
II Principles of Absorption McCoy H&L,pp. 27-45; P&T,pp. 202-222
III Principles of Distribution McCoy H&L,pp. 45-55; P&T,pp. 227-276
IV Principles of Elimination McCoy H&L,pp. 107-117; P&T,277-288
V Kinetics of Drug Action; part I McCoy P&T Chapter 4
VI Kinetics of Drug Action; part II McCoy P&T Chapter 4
VII MID-TERM EXAM McCoy  
VIII Pharmacogenetics Mukhtar P&T,pp. 470-522
IX SPRING BREAK    
X Pharmacogenetics Mukhtar P&T,pp. 470-522
XI Molecular basis drug action Rorke P&T, pp. 43-68
XII Receptor function and specificity; nuclear versus membrane receptors Rorke P&T, pp. 103-200
XIII Cell Death Rorke Review article
XIV Chemical Teratogenesis Rorke P&T, pp. 776-791
XV Drug Resistance Rorke P&T, Chapter 9
XVI FINAL EXAM Rorke  

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