Skinergy Dermatology | January/February 2015
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Unexplained Multiple Melanomas affecting siblings generates research for new causes of melanomas in adolescents and young adults.

Dr. Joshua Arbesman in the Department of Dermatology has obtained preliminary funding to sequence all the family’s expressed genes. It is hoped that he can determine whether a new underlying mutation results in this condition. Additionally, we are also growing stem cells from the patients' skin to make melanocytes, the pigment producing cells and the cells that turn into melanoma, to find which genetic differences between the melanocytes of the affected siblings and their parents' melanocytes are most important. We hope to use this information to diagnosis children and young adults in this family and others who may be at high risk, to make new melanoma mouse models and to further our understanding of melanoma development.

Dr. Arbesman is collaborating with Dr. Kevin D. Cooper, Professor & Chair, Case Western Reserve University and University Hospitals Cleveland Medical Center (more about Dr. Cooper) Barbara Bedogni, Assistant Professor, Case Western Reserve University (more about Dr. Bedogni) and Dr. Paul Tesar, Associate Professor, Case Western Reserve University  (more about Dr. Tesar ) in this project.  The project is integrated with the multidisciplinary Melanoma Program and efforts of the Department of Dermatology and the Angie Fowler Adolescent and Young Adult Cancer Institute at University Hospitals Rainbow Babies and Children’s Hospital.



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