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Thomas McCormick, Ph.D.
Thomas McCormick, Ph.D.
Associate Director for Basic Science Research, Murdough Family Center for Psoriasis
Research Operations Director Skin Diseases Research Center (SDRC)
Associate Professor of Dermatology
Office: Case Western Reserve University, Biomedical Research Building, Rm 530
Phone: (216) 368-0238
Fax: (216) 368-0212
Dr. McCormick is an internationally recognized expert in the immuno-pathogenesis of psoriasis. Dr. McCormick was the inaugural recipient of the Eugene Farber Award from the Society for Investigative Dermatology for excellence in research in psoriasis. He and his colleagues hold several patents including the photodynamic therapy compound phthalocyanin-4, currently in Phase I clinical trials for psoriasis. Dr. McCormick has published extensively on the immunology of psoriasis and several other cutaneous diseases and is the author of more than 50 primary peer-reviewed research articles, numerous review articles and text book chapters. Dr. McCormick’s research and training has been supported by grants from the National Institute of Arthritis and Musculoskeletal and Skin Diseases, the National Heart Lung and Blood Institute, the National Institute on Drug Abuse, the National Institute of Dental and Craniofacial Research and the National Cancer Institute. Dr. McCormick is a member the American Association of Immunologists and the Society for Investigative Dermatology.
Dr. McCormick’s current research focuses on cutaneous immune regulation and innate immunity. Dr. McCormick’s laboratory group addresses the role of regulatory T cells in psoriasis. Understanding the function and control of regulatory T cells in psoriatic and non-psoriatic individuals will be key to preventing autoimmune responses. Dr. McCormick has identified several candidate genes specific to regulatory T cells in both normal and psoriatic patients. Isolating and characterizing these regulatory T cell response elements is one current focus of research for Dr. McCormick’s laboratory group.
Dr. McCormick’s second avenue of research is the innate immune response of epithelial cells. Dr. McCormick and his colleagues in the School of Dental Medicine are applying comparative proteomics between immune-competent and immuno-compromised mucosae to address the innate immune response to bacterial and viral challenges.