Blueprint - 2006
WEEK 1
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WEEK 2
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*Comment #1: Pharmacodynamics:
Drugs exert their action via a limited # of mechanisms. This allows one the present a framework to describe drug action, quantify those actions, and relate both the actions & its quantification 1)at the cellular and tissue and whole organism level & additionally 2)over an entire population
To understand and become proficient in this material, the student should
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Distinguish the concepts and graphical expression of graded log dose-response curves, including their slope, potency, efficacy, and variability
- Distinguish the relative importance of efficacy and potency in the clin setting
- Identify relative potency & efficacy of drugs from graphical presentations
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Distinguish the concepts & graphical expressions that define agonist, antagonist, partial agonist/partial antagonist, and inverse agonist.
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WEEK 3
Need to get “sheets” for Facilitators Esophageal Disease case - Heartburn
Develop new cases for the year, keep some old lectures Post Stroke Pt case – dysphagia
Liver Case – Tylenol Overdose
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WEEK 4
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Comments #2:
Myosin/Actin Biocehemistry and Cross-Bridge Regulation
Ca Regulation of Actin/Myosin Interaction in Striated vs Smooth Muscle
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WEEK 5
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*Comment 3 (a) Classes of Transport Proteins
(b) Na, K and Ca Homeostasis at Cellular Level
*Comment 4 ADD TO SCHED - Nerve resting potention & action potential (1 hr large grp/3hrs sm group)
*Comment 5 Learning Objectives for Fundamental Principles of Pharmacology:
Absorption: To understand absorption process, student should be able to
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Be able to define passive, non-ionic diffusion and apply Fick’s Principle of diffusion to the process of drug absorption. Describe the influence of the drug’s pKa, the pH of the compartment the drug is in, the drug’s lipid solubility, and drug’s concentration gradient across membranes on these processes.
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Describe how changes gastric emptying rate, surface areas of the GI tract, and intestinal blood flow affect rate and/or extent of absorption.
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Distinguish the pharmacological effects of changes in rate of absorption and extent of absorption.
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Describe how changes in disintegration and dissolution of drug formulations affect rate and/or extent of absorption.
Distribution:
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Students should be able to relate specific properties of therapeutic agents (drugs) to specific properties of different tissues in order to predict:
a) the relative amount of a therapeutic agent that will distribute to different regions of the body, b) the relative rate of distribution of the agent to these different regions, and c) the relative duration of time that the agent will reside in the different regions.
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The student should be able to apply the above relationships to problems involving relative drug distribution. For example, to accelerate delivery of a drug administered intramuscularly to a patient with poor perfusion of peripheral tissues (e.g., hypovolemic shock), plasma volume should be replenished.
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The student should be able to apply the concept of “volume of distribution” (VD) as a proportionality constant to determine loading dose or initial concentration of drug in the plasma.
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The students should be able to describe drug-drug interactions involving competition for binding sites in the plasma or peripheral tissues and particularly be able to distinguish those that do not affect therapeutic outcome from those that do.
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WEEK 6
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WEEK 7
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WEEK 8
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WEEK 9
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WEEK 10
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WEEK 11
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WEEK 12
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