NINDS Center for SUDEP Research Pilot

If this is your first time using WebGrants, you will need to register online at http://webgrants.case.edu. Once you have registered, you will receive an email with your user name and password. The registration process can take up to 24 hours, so applicants are strongly advised to register for an account as soon as possible. Last minute registrations are NOT guaranteed to be approved prior to the deadline. Extensions of the deadline will NOT be given for late registrants.

The Center for SUDEP Research  (CSR) has been established to study Sudden Unexpected Death in Epilepsy (SUDEP). This Epilepsy Center Without Walls includes over 40 clinicians and scientists from 14 institutes across the U.S. and U.K. This five-year research initiative is supported by the National Institute of Neurological Disorders and Stroke at the National Institutes of Health (NIH) and brings together many of the leaders in the field of SUDEP research. The current grant RFA is generously funded by UCB.

SUDEP is the sudden and premature death of a person with epilepsy without apparent or known cause of death. It is the most common cause of premature mortality for people with epilepsy. Individuals with refractory epilepsy have a 35% lifetime chance of succumbing to SUDEP. There are currently no targeted treatments or devices available to prevent it. The cause of SUDEP is unknown, but research efforts have centered on structural and/or functional defects in brain areas that control cardiovascular and respiratory functions. Such abnormalities can cause breathing and heart rate disruptions following a seizure, which in a subset of cases, are catastrophic and lead to sudden death.

The CSR is composed of a multidisciplinary group of investigators with expertise in molecular biology, genetics, neuropathology, electrophysiology, brain imaging, epilepsy, respiratory physiology, cardiology, and bioinformatics. The team will be involved in nine projects that combine basic research and clinical findings with the common goal of quickly taking SUDEP lab results into the clinic.

Pilot Projects

The CSR seeks novel pilot projects that will address the goal of understanding and eliminating SUDEP. This pilot program will award grants to national and international researchers submitting innovative proposals that compliments and expands on the SUDEP research proposed in the CSR. The CSR plans to support one clinical pilot project (clinical trials will not be funded through this mechanism, but studies involving human subjects are allowed). Aluminum Metal Successful applicants will be expected to work collaboratively with the CSR investigators.

Eligibility

This award is available to both young and established investigators exploring cutting-edge approaches to understanding and preventing human SUDEP. International applicants and applicants from outside the field of epilepsy with novel insight into the causes and prevention of SUDEP are welcome. Investigators already funded by the CSR are not eligible to apply. All materials must be submitted in English.

Budget

Requests may be made for up to $75,000 in total (direct+indirect) costs paid over 1 year.

Deadline

  • Full Application Due: 01/31/2017
  • Earliest Project Start Date: 03/01/2017

Submission of application

All applications should be submitted to:

http://webgrants.case.edu/

And must be received by 11:59pm EST, Tuesday, January 31, 2017.

Application

Applications should include the following:

  • Specific aims (not more than 1 page)
  • Background and Research Plan (not more than 2-3 pages)
  • Biosketch of investigator(s)
  • Budget and budget justification for funding not to exceed $75,000 in TOTAL costs (direct+indirect costs) over 1 year.
  • Other support for proposed project (Do you currently have support for this project from other sources?)

For questions contact:

Technical: Related to WebGrants: Contact WebGrants Support at: webgrants-support@case.edu or call 216-368-4669.

Non-Technical: Questions regarding this RFA or your application can be directed to Anita Zaremba at axz2@case.edu or call 216-368-1803.