SMART IRB is a platform designed to ease common challenges and burdens associated with initiating multisite research and provide a roadmap for institutions to implement the NIH Single IRB Review policy. Through a flexible master IRB reliance agreement, standard operating procedures, and complementary tools and resources, SMART IRB supports and encourages collaboration and harmonization across the nation.


IND-IDE Regulatory Support Core

Online Resources

For online help, such as SOP manuals, policies and FAQs visit the SMART IRB website.


In The News

March 23, 2017 - NIH achieves milestone to accelerate multisite clinical studies: CTSA Program paves way for nationwide single IRB model.

April 14, 2017 - Welcome to the Ambassador Newsletter: Read on for updates on upcoming webinars, available slide decks, sign-on status, and harmonization efforts.

May 4, 2017 - While institutions have already begun using the SMART IRB Agreement to enable single IRB review for their studies, SMART IRB launched the online reliance system, providing Participating Institutions and their investigators with a centralized system to request, track, and document reliance arrangements. During the month of May, there are also several opportunities to attend two important webinars: Getting started with SMART IRB and Implementing the SMART IRB Agreement.

September 25, 2017 - The date that the NIH Single IRB Review Policy goes into effect. Starting September 25, any institution engaged in federally-funded multisite research must use a single IRB. SMART IRB facilitates this process, so it is important for institutions to join now to start implementing this platform for their studies.


For more information, contact:

Kathy Lawry, MSSA, CIP, SMART IRB Ambassador: