FUNDING OPPORTUNITY: Therapeutics for Rare and Neglected Diseases (TRND) Program (NOT-TR-13-007)

The National Center for Advancing Translational Sciences (NCATS), Division of Preclinical Innovation (DPI) is announcing an open opportunity to submit proposals to collaborate with the Therapeutics for Rare and Neglected Diseases (TRND) program.

The TRND program performs preclinical and early clinical development of new drugs for rare and neglected tropical diseases, and develops new technologies and paradigms to improve the efficiency of therapeutic development for these diseases. The operational model of TRND is collaboration between intramural NCATS drug development scientists and partners having promising leads and disease/target knowledge, but lacking the expertise or resources to develop these projects into clinical stage programs attractive to biopharmaceutical or other suitable organizations. TRND is establishing collaborations with researchers in the public and private sectors to together “de-risk” rare and neglected tropical disease drug development projects by accomplishing lead optimization through an Investigational New Drug (IND) application with the Food and Drug Administration (FDA), and in limited circumstances, proof-of-concept human studies.

This Notice is being provided to allow potential applicants sufficient time to contact the Solicitation Coordinator to discuss development of meaningful collaborations and responsive proposals. TRND utilizes a Letter of Intent (LOI)/pre-application teleconference process.

This announcement for collaboration will not use NIH activity codes. Details of the opportunity can be found here.