2015 Awardees

The CTSC has provided pilot research funding to investigators and scholars.

The Clinical and Translational Science Collaborative is pleased to announce the awarding of the 2015 Pilot Project Awards to clinical and translational investigators of Case Western Reserve University, and its partner institutions.




Annual Pilot Awardees


Name Institution Project Title Amount
Ozan Akkus CWRU-MAE Point of Care Detection of Urinary Stones for Improved Care of Stone Patients $15,235.35
Norbert Avril UHCMC PET Guided Inhibition of Metabolic Pathways in Ovarian Cancer $50,000.00
Jane Corteville UHCMC Measurement of Fetal Cerebral Oxygen Levels Using Photoacoustic Spectroscopy $40,000.00
Fatema Ghasia CCLCM Neuro-modulation: A Novel Treatment Strategy in Amblyopia Management $50,000.00
Frank Jacono VAMC Developing Predictive Biomarkers by Modeling Inflammation-induced Changes in Cardiorespiratory Variability Dynamics $46,213.50
Siran Koroukian CWRU-SOM Evaluating the Utility of the Linked MetroHealth Electronic Health Records and CareSource Claims Data in Health Services, Outcomes, and Policy Research $49,833.33
Matthew Schiefer VAMC Developing Stimulus Waveforms for the Splanchnic Nerves that Mimic Eating to Reduce Excess Body Weight in Obese Rodents $48,717.82

Core Utilization Awardees


Name Institution Project Title Amount
Donald Anthony CWRU-SOM Role of LPA subtype in immune activation during HCV, HIV and HCV-HIV infection $10,000.00
Eli Bar CWRU-SOM Tumor initiation - site does matter $10,000.00
Elma Baron UHCMC Effects of escalating doses of Pc 4-PDT in the treatment of CTCL $10,000.00
James Basilion CWRU-SOM Development of a novel PSMA ligand for nuclear imaging and radiotherapy of both primary and disseminated prostate cancer $9,215.00
Erics Berggren MHMC The Impact of Gestational Weight gain on Maternal Energy Expenditure Changes in a Pregnant Cohort $9,958.00
Jessica Berthiaume CWRU-SOM Positive metabolic remodeling drives the cardioprotective effect of high fat after myocardial infarction $10,000.00
Farren Briggs CWRU-SOM Characterizing bone marrow mesenchymal stem cell genomic signatures in multiple sclerosis $9,910.00
J. Mark Brown CCLCM Lipidomic Profiling of Glioblastoma-Derived Cancer Stem Cells $9,700.00
Hulya Bukulmez MHMC Pericytes/CD-146+ Human Bone Marrow Derived Mesenchymal Stem Cells as Innovative Cell Treatment for Autoimmune Inflammatory Vaculitis $10,000.00
Mark Cameron CWRU-SOM Transcriptomic Signatures of Increased Susceptibility to TB with Aging $10,000.00
Ernest Chan CWRU-SOM Sequencing Individuals for CYP2D6 Polymorphism Associated with Primaquine Effectiveness $7,750.00
John Crabb CCLCM Improved Quantitative Assay for CEP-Ethanolamine Phospholipids as Plasma Biomarkers for AMD $10,000.00
Michael Decker CWRU-SON Biologic Determinants of Exercise-Mediated Symptom Reduction in Chronic Fatigue $9,888.00
Analisa DiFeo CWRU-SOM Identification of deferentially expressed lincRNAs in Platinum-Resistant Ovarian Cancer Cells by RNA-seq $10,000.00
Edward Gilmore UHCMC Generation of mice with human PNKP mutations using CRISPR/Cas9 technology $9,630.00
Sanjay Gupta CWRU-SOM Correlation of AMP-activated protein kinase phosphorylation status, activity, and protein expression with prostate cancer progression to castration-resistance and metastasis in human archived specimens $9,730.00
Neetu Gupta CCLCM Use of gene expression profiling to reveal novel therapeutic targets in aggressive B cell lymphomas $9,867.00
Stephanie Hagstrom CCLCM In Vivo Modeling of Mutant TULP1 $9,830.00
Adonis Hijaz UHCMC Differential gene expression in human mesenchymal stem cells applied therapeutically in a rat model of acute stress urinary incontinence compared with injection into uninjured rats $9,870.00
Takhar Kasumov CCLCM HDL Proteome Dynamics in Patients with Non-alcoholic Fatty Liver Disease (NAFLD) $9,100.00
John Kirwan CCLCM Mitochondrial Fission and Fragmentation: A novel pathway for treating diabetes $9,991.20
Mark Lauer CCLCM Screening pharmacologically active compounds for inhibitors against a key enzyme that regulates airway hyperreactivity in asthma $5,000.00
Sethu Madhavan MHMC Generation and Validation of Monoclonal Antibody Against APOL1 for Quantitative Assessment of Human Kidney Tissue $8,207.00
Christine McDonald CCLCM Dietary Suppression of Antibacterial Defense $7,967.00
Tingwei Mu CWRU-SOM Identification of the Interactome of Blood Pressure-Associated Vanin-1 $9,970.00
Robin Norris UHCMC Evaluation of Cdk5 Inhibitors with Chemotherapy for the Treatment of Pediatric Malignancies $9,900.00
Padmanabhan Pattabiraman CWRU-SOM Proteomic analysis of aqueous humor during pubertal development and aging in rabbits $10,000.00
Agne Petrosiute UHCMC Modulation of Tumor Immune Surveillance by Cyclin-dependent Kinase 5 $8,700.00
Ofer Reizes CCLCM An Integrated Pathway Approach to Modulate Self-Renewal in Triple Negative Breast Cancer $10,000.00
Rachel Scheraga CCLCM Endotoxin-Induced Macrophage Phagocytosis Depends on Mechanotransduction through the Transient Receptor Potential Vanilloid 4 (TRPV4) Ion Channel $10,000.00
Eileen Seeholzer MHMC Metaboloss for MetroHealth Weight Watchers at Work participants: Feasibility and acceptability $4,738.00
Julian Stelzer CWRU-SOM Identification of novel cMyBP-C signaling targets in heart failure $9,960.00
John Tilton CWRU-SOM Characterizing the Acetylome of CD4+ T-cells to Identify Anti-HIV Targets $10,000.00
Jennifer Yu CCLCM Creation of Conditional Mouse Model to Study Sema3C-mediated Gliomagensis $10,000.00
Qing Zheng CWRU-SOM Prevention of Hearing Loss in Mice by CRISPR/Cas9 Editing of Germline DNA $9,930.00