2013 Awardees

The CTSC has provided pilot research funding to investigators and scholars.

The Clinical and Translational Science Collaborative is pleased to announce the awarding of the 2013 Pilot Project Awards to clinical and translational investigators of Case Western Reserve University, and its partner institutions.




Annual Pilot Awardees


Name Institution Project Title Amount
Micheala Aldred CCLCM New therapeutic approaches in Pulmonary Arterial Hypertension $49,950.00
Matthew Cooney UHCMC Evaluation of alpha-methylacyl-CoA racemase (AMACR) as a Non-Invasive Diagnostic Biomarker for Prostate Cancer $41,079.00
Efstathios Karathanasis CWRU Early detection of micrometastasis using a nanochain and MRI $49,952.00
John Kirwan CCLCM Unlocking the Mechanisms of Type 2 Diabetes Remission After Gastric Bypass: Relationship Between Stimulus Secretion Coupling Mechanism, Beta Cell Morphology, and Incretin Secretion $49,947.00
Li Li CWRU Human Beta-Defensin-3 (hBD-3): A Novel Biomarker for Early Colon Neoplasia $49,999.00
Ann Williams CWRU Diabetes SystemCHANGE(TM): community-based peer support for people with diabetes $50,000.00

Core Utilization Awardees


Name Institution Project Title Amount
Donald Anthony UHCMC Role of ENPP2 and LGALS3BP in immune activation during HCV, HIV and HCV-HIV infection $10,000.00
Eli Bar CWRU-SOM Evaluate the relationship between intracellular pH and Glioblastoma Tumor Initiating Cell identity $9,955.00
Ilya Bederman CWRU-SOM Unraveling behavioral alterations in cystic fibrosis mice $8,600.00
Erica Campagnaro UHCMC Oncology Nurses' Barriers to Discussion of Clinical Trial Therapy with Cancer Patients - Qualitative Analyses and Instrument Development $10,000.00
Ritu Chakravarti CCLRI Identification of post-translational modifications on 14-3-3 in Vasculitis $8,600.00
Shu Chen CWRU-SOM Identification of novel substrates of LRRK2, a Parkinson disease associated kinase $10,000.00
Sanjay Gupta UHCMC Effect of Synergistic Simvastatin and Metformin Chemotherapy in Mouse Model of Metastatic Castration-Resistant Prostate Cancer (RESUB) $10,000.00
Evren Gurkan-Cavusoglu CWRU-CSE Analysis of the Cell Cycle Dynamics for fludarabine or ABT-737 resistant Nalm-6 cells $8,970.00
Donna Hansel CCLCM Development of a Bladder Cancer Urine Biomarker Core Utilization Pilot Grant $10,000.00
Sudha Iyengar CWRU-SOM The role of transcription factor 4 (TCF4) in the corneal endothelium and susceptibility to Fuchs Dystrophy $10,000.00
Mukesh Jain UHCMC Circadian regulation of cardiac response to stress: a transcriptome study of cardiac KLF15 null mice $9,960.00
Takhar Kasumov CCLCM Analysis of the potential role of circulating bile acids in the improved metabolic profile induced by Roux-n-Y gastric bypass surgery in obese type 2 diabetic patients $7,664.80
David Kennedy CCLRI Paraoxonases in Cardio-Renal Syndrome $10,000.00
Ruth Keri CWRU-SOM Overexpression of two breast tumor initiating genes, RPL39 and MLF2, for the evaluation of mammary gland development and tumor initiation/progression in mice $9,000.00
John Kirwan CCLCM Obesity-Induced Diabetes - Novel Protein Targets for Diabetes Remission after Bariatric Surgery $9,936.00
Minh Lam UHCMC PDT induces calcium-mediated apoptosis in fungal pathogens $10,000.00
Thomas McCormick UHCMC A transgenic mouse model for Aquaporin-3 and Aquaporin-10 over-expression in inflammatory skin diseases $6,000.00
Edward Medof CWRU-SOM Evidence for a plasma membrane complex containing C5a receptor (C5aR), IL-6-receptor (IL-6R), and vascular endothelial cell growth factor receptor-2 (VEGFR-2) that governs vascular endothelial cell (EC) viability and growth signaling?. $10,000.00
Helen Salz CWRU-SOM The Drosophila ovary: an in vivo model for stem cell biology and tumorigenesis $9,767.00
David Serre CCLCM Simultaneous Reconstruction of Multiple Haploid Plasmodium vivax Genomes from Complex Infections by Dilution Separation and Genome Sequencing $8,000.00
Neelesh Sharma UHCMC Microarray gene expression analyses to identify pharmacodynamic marker of erlotinib and quinacrine in non-small cell lung cancer (NSCLC) $10,000.00
Catherine Stein CWRU-SOM Exploration of pathways underlying resistance to M. tuberculosis infection $10,000.00
Mary Step Metro Observational Coding of Patient Participation in Clinical Encounters $10,000.00
Carlos Subauste UHCMC Identification of inhibitors of CD40 signaling $10,000.00
Derek Taylor CWRU-SOM Promoting cancer cell death by selective induction of telomere instability $10,000.00
Angela Ting CCLCM Genetic determinants of resistance to DNA demethylating agent, Decitabine $9,993.00
Lance Vernon CWRU-DEN Immune and Inflammatory Consequences of Intensive Periodontal Disease Treatment in HIV+ Adults $9,928.80
David Wald UHCMC Genetic changes during AML development and progression $9,973.00
Liwen Wang CWRU-SOM HIV-1 antigen $10,000.00
Yu Chung Yang CWRU-SOM Transcriptome analysis of hematopoietic stem cells in the hypoxic niche $10,000.00
Youwei Zhang CWRU-SOM Roles of long non-coding RNAs (lncRNAs) in DNA damage response $10,000.00
Peter Zimmerman CWRU-SOM Population Genomics of the human parasite Wuchereria bancrofti $7,750.00

Themed Awardees


Name Institution Project Title Amount
From Grant:Explorys Collaborative 2012
David Kaelber MetroHealth Using Explorys to Track Case CTSC-wide Obesity Rates $20,000.00

Urban Health Awardees


Name Institution Project Title Amount
Corrilynn Hileman Metro Individual and System-Based Approach to Improving HIV Testing in Cleveland Youths $4,411.00
Siran Koroukian CWRU-SOM Evaluating return on investment for grants by Komen Northeast Ohio $12,000.00
Susanne Wish-Baratz CWRU-SOM North Star Collaborative - Anatomy Camp $10,000.00