2012 Awardees

The CTSC has provided pilot research funding to investigators and scholars.

The Clinical and Translational Science Collaborative is pleased to announce the awarding of the 2012 Pilot Project Awards to clinical and translational investigators of Case Western Reserve University, and its partner institutions.




Annual Pilot Awardees


Name Institution Project Title Amount
Efstathios Karathanasis CWRU Improved tumor oxygenation using an ethyl nitrite-loaded nanoparticle delivery system $49,999.98
Kiju Lee CWRU Feasibility evaluation of a customizable social robot for behavioral assessment and intervention for children with autism spectrum disorders (ASD) $50,000.00
Svetlana Pundik LSCVAMC Feasibility of enhancing recovery of sensory deficits after stroke with rTMS $49,974.17
Yogen Saunthararajah CC Development of a Natural Product Class into Potent Lysine Demethylase Inhibitors and Activators of Tumor Suppressor RB $35,000.00
Nicole Seiberlich CWRU Evaluation of Cardiac Functional Parameters in Patients Using Non-Gated, Free-Breathing Cardiac Magnetic Resonance Imaging $43,086.63
Neelesh Sharma UHCMC Modulating tumor vascular permeability by deletion/inhibition of sphingosine kinase-1 to enhance the response to chemotherapy in lung cancer $50,000.00
Mei Zhang CWRU Adoptive immunotherapy using ex vivo activated melanoma-draining lymph node (TDLN) T cells against human melanoma xenografts $49,998.50

Core Utilization Awardees


Name Institution Project Title Amount
Derek Abbott CWRU-SOM Transcriptomics to identify biomarkers of successful RIP2 kinase inhibition in inflammatory disease $10,000.00
Micheala Aldred CC Identification of microRNAs that are dysregulated in Pulmonary Arterial Hypertension $9,855.00
Kewal Asosignh CC Common proangiogenic and fibrocyte progenitor cell in asthma $9,506.40
Robert Bonomo LSCVAMC Multidrug Resistant Klebsiella pneumoniae in Northeast Ohio: linking antibiotic resistance to pathogenesis $8,260.00
Kenneth Cummings CC A Comparison of Epidural Analgesia and Traditional Pain Management Effects on Outcomes after Gastric Cancer Resection: A Population based study $10,000.00
Rob Ewing CWRU-SOM Defining the distinct pluripotent states of different types of embryonic stem cell $10,000.00
Stephen Fink CWRU-SOM Mechanisms of vitamin D resistance in colon cancer $8,175.00
Kishore Guda CWRU-SOM Characterizing The Biological Role Of GALNT12 Gene In Colon Tumor Pathogenesis $8,300.00
Yiping Han CWRU-SODM Comparative genomic studies of Fusobacterium nucleatum to identify genes unique for causing intrauterine infections $10,000.00
Sudha Iyengar CWRU-SOM Using next-generation sequencing to comprehend transcription regulation of CFH in the retina $9,996.00
Michaela Koontz UHCMC Childhood Obesity and Fat Distribution: The Role of Perinatal Programming $9,993.00
Carole Liedtke CWRU-SOM Protein Scaffolds Regulate NKCC1 membrane expression and function $9,900.00
Monica Montano CWRU-SOM Role of HEXIM1 in the protection against ischemic stress $10,000.00
Tingwei Mu CWRU-SOM Identifying a GABAA Receptor Interactome as Therapeutic Targets to Ameliorate Idiopathic Epilepsy $9,900.00
John O'Toole MetroHealth Transgenic murine expression of human APOL1 with and without kidney disease risk variants in the podocyte $9,400.00
Tomas Radivoyevitch CWRU-SOM The Intracellular half-life of decitabine triphosphate $10,000.00
Ofer Reizes CC Leptin and leptin receptor gene signature in breast cancer stem cells $8,200.00
Lisa Rogers UHCMC Comparison of MRI morphologic characteristics in surgically proven radiation necrosis versus recurrent brain tumor and correlation with histologic profiles $9,963.00
Priyadarshini (Preenie) Senanayake CC Angiotensin (1-7) a specific therapeutic target for the treatment of retinal diabetic pathology $10,000.00
Cheryl Thompson UHCMC Sleep, Genetic Variants in Circadian Rhythm Genes and Breast Cancer $9,350.00
Saba Valadkhan CWRU-SOM Analysis of the proteome of a long non-coding RNA and its impact on gene expression $9,930.00
Richard Wilson MetroHealth Percutaneous Peripheral Nerve Stimulation for Chronic Shoulder Pain in the Spinal Cord Injured $10,000.00
Sichun Yang CWRU-SOM Mass spectrometry analyses of human estrogen receptor alpha samples modified by anti-cancer drugs $9,960.00
Yu-Chung Yang CWRU-SOM Metabolic Control of Hematopoietic Stem Cells $10,000.00
Elizabeth Yohannes CWRU-SOM Histone modification pattern in human oral epithelial cells emerging from chronic HIV infection $9,570.00

CTSC Partnership Pilot Awardees


Name Institution Project Title Amount
From Grant:Pediatrics 2012
Agne Petrosiute UHCMC Recruitment of immune cells to Medulloblastoma tumor microenvironment and their role in tumor evasion $10,000.00
From Grant:SDRC 2012
Saba Valadkhan CWRU-SOM Analysis of the non-coding transcriptome of the aging skin $10,000.00

Pediatrics Awardees


Name Institution Project Title Amount
Claudia Hoyen UHCMC $10,000.00

SDRC Awardees


Name Institution Project Title Amount
Marie Tuttle CWRU-SOM Longitudinal microbiome shifts may affect innate immune responses in delayed wound healing $10,000.00

Themed Awardees


Name Institution Project Title Amount
From Grant:Bioinformatics 2012
Rob Ewing CWRU-SOM Semantic Provenance Dashboard: a tool for integration, organization and querying across diverse 'omics and clinical datasets $29,996.66
Jing Li CWRU-SOM SNP calling and diversity analysis of paramyxoviruses in patients $29,978.76
Neal Meropol UHCMC TrialProspector, Automated Clinical Trials Eligibility Screening $30,000.00
Rong Xu CC/CWRU Developing a Disease Risk Knowledge Base to Search for Hypertension Genetic Variants in the Post-GWAS Era $30,000.00
From Grant:Bioinformatics 2013
Johnie Rose UHCMC Developing Information Tools for Improving Care of Colorectal Cancer Survivors $29,928.83

Urban Health Awardees


Name Institution Project Title Amount
Jessica Kelley-Moore CWRU-CAS Development and Validation of Cooking Based Nutrition Education Classes $8,700.00
Lynda Montgomery UHCMC Learning leadership through Community engagement: the Improve Children's Health Access Project $8,726.00
Robert Salata UHCMC Using Peer Educators to Improve Sexual Health in Glenville $9,400.00