2011 Awardees

The CTSC has provided pilot research funding to investigators and scholars.

The Clinical and Translational Science Collaborative is pleased to announce the awarding of the 2011 Pilot Project Awards to clinical and translational investigators of Case Western Reserve University, and its partner institutions.




Annual Pilot Awardees


Name Institution Project Title Amount
Thomas Chelimsky UH Treatment of Multiple System Atrophy with Electroconvulsive Therapy $49,973.00
Brian Grimberg CWRU-SOM Pointing out malaria infections with laser light $49,978.00
Nora Nock CWRU-SOM Revving-Up Exercise for Sustained Weight-Loss by Altering Neurological Reward and Drive (REWARD): A Pilot Study of Assisted Exercise in Obese Endometrial Cancer Patients $25,000.00
James Reynolds CWRU-SOM Liposomal Alkyl Nitrites as Novel Sources of Nitric Oxide Bioactivity $49,995.00
Carl Tyler CC Multi-level Exploration of Cancer Control Disparities in a Medically Underserved Population $47,992.00
David van Duin CC Consortium to Study Carbapenem Resistant (CR) Klebsiella pneumoniae (Kp) in Northeast Ohio (NEO) $49,876.00
Claudia Zein CC Non-invasive Predictors of Liver Fibrosis in Patients with Nonalcoholic Steatohepatitis Treated with Pentoxifylline $17,291.00
GQ Zhang CWRU-SOM FEMI: Federation of EMR and Medicaid Information for Healthcare Policy and Outcomes Research $49,909.00

Collaborative Awardees


Name Institution Project Title Amount
Thakar Kasumov CCF Ceramide as a Mediator of Obesity Induced Atherosclerosis $45,000.00
Mariana Rosca CWRU-Som Preventing the diet-induced insulin resistance. Mitochondrial approaches $45,000.00
Laura Vricella MetroHealth Blood Volume Determination in Morbidly Obese Gravidas at Term: the hydroxyethyl starch method $39,246.00
Guofang Zhang CWRU-SOM Stimulation of high-fat diet-induced obesity in rats by lipid peroxidation products $44,984.00

Core Utilization Awardees


Name Institution Project Title Amount
Ashok Agarwal CC Analyses of Catalase (CXAT0 Gene for Mutations/Polymorphisms among Male Infertility men Exhibiting Oxidative Stress $21,620.00
Ilya Bederman CWRU-SOM Real-time imaging of lipid metabolism in mouse models of cystic fibrosis $10,000.00
Ronald Blanton CWRU-SOM Genetic monitoring of an Aedes aegypti mosquito control program. $9,328.00
Leslie Bruggeman MetroHealth Apolipoprotein L1 levels and APOL1 genetic variants in HIV-infected chronic kidney disease patients $5,198.00
Gisela Chelimsky UHCMC Evaluation of Inflammatory Response Through Cytokine Measurements $10,000.00
Calvin Cotton UHCMC In vivo correction of aberrant EGF receptor trafficking in polycystic kidney disease $8,250.00
Peter DeGolia UHCMC Elders safety and well being evaluation at clinic and home to assess the risk of institutionalization $10,000.00
Cladiu Diaconu CC Assessment of the Effects of Hydration Status on the Ultrasound Evaluation of Neck Veins for Chronic Cerebrospinal Venous Insufficiency $18,775.00
Thomas Egelhoff CC Regulation of cytoskeletal force machinery within invasive cell subpopulations from primary breast tumors: a phospho-proteomic analysis $10,000.00
Frank Esper UHCMC Detection of Previously Unrecognized Respiratory Viruses by Deep Sequence Analysis $9,817.00
Eckhard Ficker MetroHealth Analysis of phenotype-genotype discordance using iPS cells derived from patients with long QT syndrome Type 2 $10,000.00
Abigail Glick UHCMC The role of regulatory T cells in the susceptibility of Down Syndrome patients to autoimmune disease $10,000.00
Craig Hodges CWRU-SOM Creation of new mouse models for Cystic Fibrosis $9,700.00
Xian Wen Jin CC Human Papillomavirus Testing can be used as the Sole Primary Screening Test for Cervical Cancer $25,000.00
Ahmad Khalil CWRU-SOM Reprogramming of cell identity by large non-coding RNAs $10,000.00
Humberto Kern Laydner CC Fluorescent Near Infrared Image-Guided Robotic Excision of Human Prostate Cancer Implanted in Mice $18,300.00
Rom Leidner UHCMC Plasma miRNA Signature of Early Stage Lung Cancer $8,865.00
John Letterio UHC Development of Engineered Melanoma cells as a Therapeutic Vehicle $10,000.00
Lili Liu UHCMC miRNAs classifiers of methoxyame and fludarabine response in phase I CLL clinical trial $8,970.00
Elizabeth Madigan School of Nursing Home Health Care PBRN for Ohio: Focus on Immunizations $6,455.00
Indu Malhotra CWRU-SOM The effect of maternal infections on B cell responses to vaccines when mediated by infant T cell responses to malarial antigens $10,000.00
Howard Meyerson CWRU-SOM Evaluation of ZAP-70 in CLL cells using Amnis Imagestream $10,000.00
Marvin Nieman UHCMC Detecting Protease Activated Receptors In vivo $8,000.00
Paul Park CWRU-SOM Generation of a mouse model for retinitis pigmentosa $10,000.00
Ela Plow CC Brain Stimulation-Aided Stroke Rehabilitation:� Neural Mechanisms of Recovery $25,000.00
Xin Qi CWRU-SOM Study of mitochondrial dynamics in neurons from patients with Huntington?s diseases $10,000.00
Haala Rokadia CC Effect of Patient Volume in Intensive Care Unit on Mortality and Length of Stay $8,000.00
Yogen Saunthararaja CC Compositional determination and evaluation of in vivo bio-distribution and efficacy of multi-modal gold nanoclusters for cancer therapy $9,270.00
Jeffrey Schelling MetroHealth Diabetic nephropathy screening for urine fatty acid biomarkers $3,000.00
Wai Hong (Wilson) Tang CC Cardiac-Specific Cellular Autoimmunity in Heart Failure $25,000.00
Cheryl Thompson UHCMC The Coding and NonCoding Transcriptome of Lung Adenocarcinoma Stepwise Progression by NextGen Sequencing $10,000.00
Erica Trapl CWRU-SOM Exploring the use of little cigars among African-American Males: A qualitative pilot study $10,000.00
David Wald UHC Proteomics based discovery of GSK3 dependent pathways $9,750.00
Zhenghe Wang CWRU-SOM Utilization of the Case Case Transgenic and Targeting Facility to produce paxillin conditional knockout mice with ES clones generated by the EUCOMM $10,000.00
Allison Webel CWRU-SON SystemCHANGE-HIV: A pilot study exploring the effect of a systems-based intervention to increase sleep behavior and physical activity $3,000.00
Wesley Williams CWRU The effect of iron on expression and function of the antimicrobial and immunomodulatory peptide beta-defensin 1 $10,000.00
Richard Wilson MetroHealth Feasibility Single-lead percutaneous NMES for SIS $10,000.00

Multi-institutional Awardees


Name Institution Project Title Amount
Michael Weiss CWRU Biological Targeting of Anopheles Reproduction by Doublesex Inhibition $22,975.00

Themed Awardees


Name Institution Project Title Amount
From Grant:2011 Community & Academic Partnership
Charles Modlin CC Cleveland Clinic - Lifebanc of Ohio Community Partnership to Promote Organ Donor Awareness and Registration among African Americans $29,999.00
Sue Flocke CWRU-SOM Enhancing farmers market use among recipients of the Food Assistance Program across 10 Cleveland neighborhoods $29,977.00
James Spilsbury CWRU-SOM Translating a Secondary-Trauma Intervention into Community Practice $24,706.00