2009 Awardees

The CTSC has provided pilot research funding to investigators and scholars.

The Clinical and Translational Science Collaborative is pleased to announce the awarding of the 2009 Pilot Project Awards to clinical and translational investigators of Case Western Reserve University, and its partner institutions.




Annual Pilot Awardees


Name Institution Project Title Amount
Joshua Augustine UH Biological and Clinical Implications of Highly Activated T cells in Chronic Kidney Disease Patients $38,822.00
Ruth Keri CWRU-SOM Identification of biomarkers of bone marrow micrometastases in HER2 positive breast cancer $74,704.00
Sumita Khatri MetroHealth Associations of Air Pollution and Obesity on Oxidative Stress in Asthma $75,015.00
John Kirwan CC Insulin Resistance: Detection of Hepatocellular Lipid Sub-Species by Magnetic Resonance Spectroscopy $74,840.00
Charles Kunos CWRU Mechanism of secondary resistance to radiation, cisplatin plus ribonucleotide reductase inhibitors $31,750.00
Jeongwu Lee CC EZH2-Mediated Polycomb Control in Glioblastoma Stem/Initiating Cells $75,000.00
Rajeev Mehlotra CWRU Influence of ethnicity and specific genetic variation on HIV/AIDS treatment response $51,340.00
Nora Nock CWRU Neurocognitive and Genetic Evaluation of Obese Endometrial Cancer Patients: A Feasibility Study $73,687.00
Luis Solchaga CWRU-ICC Development of a Potency Assay for the Immunomodulatory Activity of Mesenchymal Stem Cells $29,432.00
David Wilson CWRU Coronary Plaque Characterization with Vascular OCT Imaging $72,525.00
Assem Ziady CWRU Development & imaging of liver targeted DNA nanoparticles $74,450.00

Core Utilization Awardees


Name Institution Project Title Amount
Mark Adams CWRU-SOM Protein Expression Associated with Colistin Resistance in Acinetobacter baumannii´┐Ż $10,000.00
Ashok Agarwal CC Effects of Radiofrequency Electromagnetic Waves (RF-EMW) from Cellular Phones on Human Ejaulated Semen $24,932.00
Siwar Albashir CC Metabolic Bone Disease in Chronic Pancreatitis $14,388.00
Jill Barnholtz-Sloan CWRU Ohio Brain Tumor Study: Methylation Patterns in Benign and Atypical Meningiomas $9,900.00
Shaul Beyth CC Optimization of Systemic Treatments to Induce Circulation of Mesenchymal Stem Cells $25,000.00
Rebecca Boxer UH A Randomized Controlled Trial of Vitamin D Therapy in Older Heart Failure Patients $9,800.00
Ann-Marie Broome CWRU-SOM Noninvasive Optical Imaging of Biologic Mesh Performance in Infected Ventral Hernia Repair $9,527.00
Clemens Burda CWRU Dual-Receptor Targeted Nanoparticles for the Photodynamic Therapy of Brain Cancer $9,780.00
David Canaday VA Deleterious Consequences of Loss of CD4+ T Cell Polyfunctionality in HIV/TB Co-infection $10,000.00
Lama Chahine CC Effects of DBS for Parkinsons Disease on Symptoms of Restless Legs Syndrome and Sleep Problems $3,170.00
Prakash Chandrasekaran CC IN-VIVO Bioreactor Model to Test Repair Grafts $25,000.00
Ai-Ping Chau CC Exhaled Breath Analysis in Obstructive Sleep Apnea $25,000.00
Christina Ching CC PTEN/P13K TOR Signaling in Bladder Cancer Initiating Stem Cells $24,941.00
Michael Connor CC Antibiotic CRRT Dosing (ABCD Trial) $22,000.00
Dorr Dearborn CWRU-SOM Synthesis/validation of 11C-labeled N-methyl Serotonin for PET Imaging of the Serotonergic System $10,000.00
Katherine Dell MetroHealth MRI Biomarkers for Early Stage Detection of Diabetic Nephropathy $9,600.00
Kathleen Derwin CC Hyaluronan Treated Fascia ECM for Rotator Cuff Repair $16,200.00
Edward Diaz CC PTEN/PI3K/mTOR Signaling in Bladder Cancer Initiating Stem Cells $24,941.00
Deepa George CC Coenzyme Q 10 in Asthma Management $25,000.00
Mahmoud Ghannoum UH Community Proteomics of Oral Cavity $10,000.00
Eckhard Jankowsky CWRU Identification of Cellular RNA Targets of the DEAD-box RNA Helicase Ded1p $9,780.00
Amr Abdel Kader CC Development and Validation of a Novel Sperm Vitrification System Using the Ohio-Cryo Vitrification D $24,753.00
Jenny Kim CC VEGF R Single Nucleotide Polymorphisms as Potential Biomarkers of Sunitinib Therapy in Advanced Renal Cell Carcinoma $25,000.00
Charles Kunos UH Mechanistic Study of Secondary Resistance to Ribonucleotide Reductase Inhibitors $10,000.00
William Larchian CC Effects of Secondhand Smoke and Cigarette Smoking on Immune Responses to Bladder Cancer Therapy $25,000.00
Mathew Lesniewski CWRU-SOM Proteomic Analyses of Monocyte-Endothelium Interactions $8,400.00
Patrick Ma UH Genomic Study of Early Survivor Lung Cancer Cells Against EGFR Inhibitors for Novel Target Discovery $10,000.00
Anna Mandalakas UH Delineation of Pediatric M.tb Specific T-cell Profiles $9,786.00
Nicholas Marko CC Identification of Sub-Populations of Tumor Stem Cells Associated with Glioblastoma $25,000.00
Jesse McCarron CC The Biomechanical Relevance of Tears of the Rotator Cable $25,000.00
Rajeev Mehlotra CWRU-SOM Genetic determination of ancestry in admixed populations of HIV/AIDS patients $10,000.00
Masaru Miyagi CWRU-SOM Circadian Changes of Photoreceptor Transcriptome $10,000.00
Tyler Muffly CC Lower Urinary Tract Symptom Evaluation of Women with Uterine Leiomyomas $23,000.00
Pranab Mukherjee CWRU-SOM Fusarium Biofilm Proteomics $10,000.00
John O'Toole MetroHealth Proteomic Approach for the Characterization of XPNPEP3 Function in the Mitochondria $9,750.00
Tammy Owings CC Influence of the Throw Right Program on the Kinematics of Pitching $23,225.00
Mark Rood UH Patient-Centered Medical Home Core Measures Study $9,875.00
John Ryan CC The Impact of a Randomized Controlled Trial of Knee Arthroscopy on Clinical Practice $24,897.00
Mary Samplaski CC The Use of Nanoparticle Technology in the Treatment of Non-Muscle Invasive Bladder Cancer $25,000.00
Rahul Seth CC Facial Nerve Neuropathy and the Effects of Flucocorticoids $16,000.00
Rakesh Sharma CC Role of Curcumin in Reducing Oxidative Stress-induced Sperm Damage $24,907.00
Daniel Shoskes CC Neuroendocrine Evaluation of Men with Chronic Pelvic Pain Syndrome $21,250.00
Ruth Siegel CWRU-SOM Gene Expression in the Pons and Regulation of Respiration: Role of GABA-A Receptors $8,890.00
Tyler Stevens CC Pilot Study of Oxidative Stress Pathways in Chronic Pancreatitis $19,577.00
Vairavan Subramian CC Partial Nephrectomy $24,999.00
James Swain CWRU-SOM From Aberrant Crypt to Adenocarcinoma: Proteomics of intestinal Tumorigenesis $9,600.00
Alan Tartakoff CWRU-SOM Transcriptional Profiles to Understand Pseudomonas aeruginosa Toxicity $10,000.00
Lance Vernon CWRU-SODM Longitudinal Analysis of Periodontal and Vascular Disease Data in HIV+ Adults $10,000.00
David Wald UH Gene Expression Analysis of Novel AML Differentiation Agents $10,000.00
Nicole Ward CWRU-SOm Label Free Analyses of Differentially Expressed Proteins in the KC-Tie2 Mouse Model of Psoriasis $9,000.00
Robert Wesolowski CC Pilot Study of Effects of Zoledronate on Gamma-Delta Tcells and Myeloid Derived Suppressor Cells $16,699.00
Wesley Williams CWRU Susceptibility of Cationic Antimicrobial Peptides to Dicarbonyl-induced Adduct Formation in vitro $10,000.00
Chris Winkelman CWRU Myogenic Markers of Activity Response in ICU Adults $9,420.00
Massarat Zutshi CC A Study to Determine the Role of Cytokines in MSC Homing to the Anal Sphincter after Injury $20,000.00