Experimental and Analytic Systems Biology

The Experimental and Analytic Systems Biology Core provides study design consultation and highly standardized platforms for conducting proteomic and transcriptomic assays, as well as the expertise and workflows to perform bioinformatic analysis that integrates omic data types with clinical or functional data, etc. Our assay workflows are optimized for many difficult sample types and our analytics are data-type independent. We therefore partner with a variety of clinical, CFAR and university cores, such as the CFAR Immune Function and Virology, Next Generation Sequencing and Imagine Cores and CWRU Genomics Core, for those researchers who require a true top-to-bottom systems biology analysis. The core also houses the Inter-CFAR Bioinformatic Network to facilitate partnerships between CFARs, providing access to other omic technologies, bioinformatic analysis and meta-analysis for external CFAR members, and data integration between CFARs.

General Information:

Check out the Core Resources page for a listing of Instruments and Computational equipment available through the Core.

Proteomics: A variety of proteomic assays and services are available, including structural proteomics, 2D DIGE, PTM, label-free and data analysis. For more information, please visit the Core Services page or contact Ms. Schlazter.

Transcripomics: We provide RNA isolation and sequencing library generation services, with Illumina-based sequencing in partnership with the CWRU Genomics Core, on a wide variety of animal model and patient sample types, including small specimens (e.g. finely sorted cells, biopsies). For more information, please visit the Core Services page or contact Dr. Cameron. Please feel free to contact the core directors with any other questions.

Researchers who utilize CWRU/UH Center for AIDS Research services are strongly encouraged to cite the CFAR in all publications resulting from the use of CFAR services. CWRU/UH Center for AIDS Research: NIH Grant Number: P30 AI036219.