Notable News
- New Publication
Wiredja DD, Tabler CO, Schlatzer DM, Li M, Chance MR, Tilton JC. Global phosphoproteomics of CCR5-tropic HIV-1 signaling reveals reprogramming of cellular protein production pathways and identifies p70-S6K1 and MK2 as HIV-responsive kinases required for optimal infection of CD4+ T cells. Retrovirology. 2018;15(1):44. Epub 2018/07/05. doi: 10.1186/s12977-018-0423-4. PubMed PMID: 29970186; PMCID: PMC6029029.
- New Publication
Alvarez-Carbonell D, Ye F, Ramanath N, Dobrowolski C, Karn J. The Glucocorticoid Receptor Is a Critical Regulator of HIV Latency in Human Microglial Cells. Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology. 2018. Epub 2018/07/11. doi: 10.1007/s11481-018-9798-1. PubMed PMID: 29987742.
- New Publication
Mbonye U, Wang B, Gokulrangan G, Shi W, Yang S, Karn J. Cyclin-dependent kinase 7 (CDK7)-mediated phosphorylation of the CDK9 activation loop promotes P-TEFb assembly with Tat and proviral HIV reactivation. The Journal of biological chemistry. 2018;293(26):10009-25. Epub 2018/05/11. doi: 10.1074/jbc.RA117.001347. PubMed PMID: 29743242; PMCID: PMC6028954.
- New Publication
Oliveira VHF, Perazzo JD, Josephson RA, Deminice R, Webel AR. Association Between the 6-Minute Walk Test Distance and Peak Cardiorespiratory Fitness Among People Living with HIV Varies by Fitness Level. The Journal of the Association of Nurses in AIDS Care : JANAC. 2018. Epub 2018/06/19. doi: 10.1016/j.jana.2018.05.005. PubMed PMID: 29910102.
- Four professors recognized for scholarly contributions with Faculty Distinguished Research
...
Research is at the core of Case Western Reserve University, and our faculty make groundbreaking discoveries and inventions every day. Across the university, faculty members solve important problems, advance new technologies, and pave the way in emerging industries.
- In first-ever study, School of Medicine researchers to pair monoclonal antibody with body’s own
...
A Case Western Reserve University School of Medicine researcher received a $2.5 million grant from Gilead Sciences, a California-based biopharmaceutical company, to see if two so-far separately used AIDS treatments are even more effective when used as a pair.
- Medicine’s Rafick-Pierre Sékaly speaks on new HIV treatment study
Science Magazine: Rafick-Pierre Sékaly, the Richard J. Fasenmyer Professor of Immunopathogenesis and co-director of the Center for AIDS Research Proteomics and Systems Biology Core, spoke about a new study on how FDA-approved drugs for rheumatoid arthritis may help patients with HIV. Sékaly also is a professor of pathology.
- New Publication
Funderburg NT, Xu D, Playford MP, Joshi AA, Andrade A, Kuritzkes DR, Lederman
MM, Mehta NN. Treatment of HIV infection with a raltegravir-based regimen
increases LDL levels, but improves HDL cholesterol efflux capacity. Antivir Ther.
2017;22(1):71-75. doi: 10.3851/IMP3091. Epub 2016 Oct 14. PubMed PMID: 27740536;
PubMed Central PMCID: PMC5516727. - New Publication
Muzaale AD, Althoff KN, Sperati CJ, Abraham AG, Kucirka LM, Massie AB,
Kitahata MM, Horberg MA, Justice AC, Fischer MJ, Silverberg MJ, Butt AA, Boswell
SL, Rachlis AR, Mayor AM, Gill MJ, Eron JJ, Napravnik S, Drozd DR, Martin JN,
Bosch RJ, Durand CM, Locke JE, Moore RD, Lucas GM, Segev DL. Risk of End-Stage
Renal Disease in HIV-Positive Potential Live Kidney Donors. Am J Transplant. 2017
Jul;17(7):1823-1832. doi: 10.1111/ajt.14235. Epub 2017 May 12. PubMed PMID:
28497525; PubMed Central PMCID: PMC5489376. - New Publication
Nixon DE, Bosch RJ, Chan ES, Funderburg NT, Hodder S, Lake JE, Lederman MM,
Klingman KL, Aberg JA; AIDS Clinical Trials Group Study A5275 Team. Effects of
atorvastatin on biomarkers of immune activation, inflammation, and lipids in
virologically suppressed, human immunodeficiency virus-1-infected individuals
with low-density lipoprotein cholesterol <130 mg/dL (AIDS Clinical Trials Group
Study A5275). J Clin Lipidol. 2017 Jan - Feb;11(1):61-69. doi:
10.1016/j.jacl.2016.09.017. Epub 2016 Oct 5. PubMed PMID: 28391912; PubMed
Central PMCID: PMC5407297. - New Publication
Bonar MM, Tilton JC. High sensitivity detection and sorting of infectious
human immunodeficiency virus (HIV-1) particles by flow virometry. Virology. 2017
May;505:80-90. doi: 10.1016/j.virol.2017.02.016. Epub 2017 Feb 21. PubMed PMID:
28235684; PubMed Central PMCID: PMC5393045. - New Publication
Garcia-Mesa Y, Jay TR, Checkley MA, Luttge B, Dobrowolski C, Valadkhan S,
Landreth GE, Karn J, Alvarez-Carbonell D. Immortalization of primary microglia: a
new platform to study HIV regulation in the central nervous system. J Neurovirol.
2017 Feb;23(1):47-66. doi: 10.1007/s13365-016-0499-3. Epub 2016 Nov 21. PubMed
PMID: 27873219; PubMed Central PMCID: PMC5329090. - New Publication
Al-Kindi SG, Kim CH, Morris SR, Freeman ML, Funderburg NT, Rodriguez B,
McComsey GA, Dalton JE, Simon DI, Lederman MM, Longenecker CT, Zidar DA. Brief
Report: Elevated Red Cell Distribution Width Identifies Elevated Cardiovascular
Disease Risk in Patients With HIV Infection. J Acquir Immune Defic Syndr. 2017
Mar 1;74(3):298-302. doi: 10.1097/QAI.0000000000001231. PubMed PMID: 27828877;
PubMed Central PMCID: PMC5303143. - New Publication
Al-Kindi SG, Zidar DA, McComsey GA, Longenecker CT. Association of
Anisocytosis with Markers of Immune Activation and Exhaustion in Treated HIV.
Pathog Immun. 2017;2(1):138-150. doi: 10.20411/pai.v2i1.199. Epub 2017 May 2.
PubMed PMID: 28713869; PubMed Central PMCID: PMC5505669. - New Publication
Fatukasi TV, Cole SR, Moore RD, Mathews WC, Edwards JK, Eron JJ; CNICS
investigators. Risk factors for delayed antiretroviral therapy initiation among
HIV-seropositive patients. PLoS One. 2017 Jul 10;12(7):e0180843. doi:
10.1371/journal.pone.0180843. eCollection 2017. PubMed PMID: 28700693; PubMed
Central PMCID: PMC5507276. - New Publication
Drozd DR, Kitahata MM, Althoff KN, Zhang J, Gange SJ, Napravnik S, Burkholder
GA, Mathews WC, Silverberg MJ, Sterling TR, Heckbert SR, Budoff MJ, Van Rompaey
S, Delaney JAC, Wong C, Tong W, Palella FJ, Elion RA, Martin JN, Brooks JT,
Jacobson LP, Eron JJ, Justice AC, Freiberg MS, Klein DB, Post WS, Saag MS, Moore
RD, Crane HM. Increased Risk of Myocardial Infarction in HIV-Infected Individuals
in North America Compared With the General Population. J Acquir Immune Defic
Syndr. 2017 Aug 15;75(5):568-576. doi: 10.1097/QAI.0000000000001450. PubMed PMID:
28520615; PubMed Central PMCID: PMC5522001. - New Publication
Belaunzarán-Zamudio PF, Azzoni L, Canaday DH, Caro-Vega YN, Clagget B, Rassool
MS, Rodriguez B, Sanne I, Sereti I, Sierra-Madero JG, Lederman MM. Immunologic
Effects of Maraviroc in HIV-Infected Patients with Severe CD4 Lymphopenia
Starting Antiretroviral Therapy: A Sub-Study of the CADIRIS Trial. Pathog Immun.
2017;2(2):151-177. doi: 10.20411/pai.v2i2.181. Epub 2017 May 9. PubMed PMID:
28736763; PubMed Central PMCID: PMC5518704.
Publications
- Absence of HIV-1 Drug Resistance Mutations Supports the Use of Dolutegravir in Uganda.
Ndashimye E, Avino M, Kyeyune F, Nankya I, Gibson RM, Nabulime E, Poon AFY, Kityo C, Mugyenyi P, Quinones-Mateu ME, Arts EJ. IDS research and human retroviruses. 2018;34(5):404-14.
- Recent Abacavir Use Increases Risk of Type 1 and Type 2 Myocardial Infarctions Among Adults With HIV.
Elion RA, Althoff KN, Zhang J, Moore RD, Gange SJ, Kitahata MM, Crane HM, Drozd DR, Stein JH, Klein MB, Eron JJ, Silverberg MJ, Mathews WC, Justice AC, Sterling TR, Rabkin CS, Mayor AM, Klein DB, Horberg MA, Bosch RJ, Eyawo O, Palella FJ, Jr. Recent Abacavir Use Increases Risk of Type 1 and Type 2 Myocardial Infarctions Among Adults With HIV. Journal of acquired immune deficiency syndromes. 2018;78(1):62-72.
- HIV-1 infection of microglial cells in a reconstituted humanized mouse model and identification of compounds that selectively reverse HIV latency.
Llewellyn GN, Alvarez-Carbonell D, Chateau M, Karn J, Cannon PM. HIV-1 infection of microglial cells in a reconstituted humanized mouse model and identification of compounds that selectively reverse HIV latency. J Neurovirol. 2018;24(2):192-203.
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