Yunmei Wang, PhD
Phone: 216-368-6268
Fax: 216-368-2951
E-mail: yunmei.wang@case.edu
Research Summary:
Yunmei Wang is a research scientist at Case Cardiovascular Research Institute, Department of Medicine, School of Medicine at Case Western Reserve University. Dr. Wang studies the mechanism underlying cardiovascular injury. Her research focus on the role of leukocyte and platelet interaction mediated by Mac-1 and GP Iba in various cardiovascular diseases such as atherosclerosis, restinosis, vasculitis etc. These research efforts may provide insights into the development of therapeutic reagents to treat cardiovascular diseases that are associated with leukocyte and platelet interaction.
Original Publications: (last 5 years)
Shimizu K., Libby P., Sakuma M., Wang YM., Mitchell RN. and Simon DI. 2008 The Leukocyte Integrin Mac-1 Promotes Acute Cardiac Allograft Rejection. Circulation 117(15):1997-2008.
Morrow, D., Wang YM.(co-first author), Croce K., Sakuma M., Sabatine MS., Gao H. PPradhan AD, Healy AM., Buros J., McCabe CH., Libby P., Cannon CP., Braunwald E. and Simon DI. 2008 Myeloid-Related Protein-8/14 and the Risk of Cardiovascular Death or Myocardial Infarction after an Acute Coronary Syndrome in the PROVE IT-TIMI 22 Trial. American Heart Journal 155(1):49-55.
Healy AM., Pickard MD., Pradhan AD., Wang YM., Chen Z., Croce K., Sakuma M., Shi C., Zago AC.., Garasic J., ; Damokosh AI., Dowie TL., Poisson L., Lillie J., Libby P., Ridker PM and Simon DI 2006 Platelet Expression Profiling and Clinical Validation of Myeloid-Related Protein-14 as a Novel Determinant of Cardiovascular Events. Circulation May16, 113919);2278-84.
Wang YM., Sakuma M., Chen Z., Ustinov V., Shi C., Croce K., Zago Ac., Jose Lopez J., Andre P., Plow E. and Simon DI 2005 Leukocyte engagement of platelet GP Iba via the integrin Mac-1 is critical for the biological response to vascular injury Circulation Nov 8;112(19):2993-3000.
Wang YM, Chen W, Simpson DM, Elion EA. Cdc24 regulates nuclear shuttling and recruitment of the Ste5 scaffold to a heterotrimeric G protein in Saccharomyces cerevisiae. J Biol Chem. 2005;280(13):13084-96.
Daniels MJ, Wang YM(co-first author), Lee M, Venkitaraman AR. Abnormal cytokinesis in cells deficient in the breast cancer susceptibility protein BRCA2. Science. 2004;306(5697):876-9.
Ni X, Zhang W, Huang KC, Wang YM, Ng SK, Mok S, Berkowitz R and Ng SW 2005 Characterization of human kallikerein6/Protease M expression in ovarian cancer. British Journal of Cancer 2005;92(5):983
Anderson J, Simpson D, Qi M, Wang YM, and Elion EA. Differential input by Ste5 scaffold and Msg5 phosphatase route a MAPK cascade to multiple outcomes. EMBO J. 2004 Jul 7;23(13):2564-76.
Wang YM and Elion EA. Nuclear export and plasma membrane recruitment of the Ste5 scaffold are coordinated with oligomerization and association with signal transduction components. Molecular Biology of the Cell: 2003;14(6):2543-58.
Cherkasova VA, McCully R, Wang YM, Hinnebusch A, and Elion E.A. A novel functional link between MAP kinase cascades and the Ras/cAMP pathway that regulates surviva. Current Biology 2003;13(14):1220-6.
Taylor SS, Hussein D, Wang YM, Elderkin S, and Morrow CJ. Kinetochore Localization and phosphorylation of the mitotic checkpoint components Bub1 and BubR1 are differentially regulated by spindle events in human cells. J. Cell Science 2001;114(pt24):4385-95.
Quayle AJ, Porter E, Nussbaum A, Wang YM, Brabec C, Yip K, and Mok S. Gene expression, immunolocalization and secretion of human defensin-5 in human female reproductive tract. American Journal of Pathology 1998;152(5): 1247--1258.
Yang A, Kaghad M, Wang YM, Gillett E, Fleming M, Dotsch V, Andrews N, Caput D and Mckeon F. P63, a P53 homology at 3q27-29, encodes multiple products with transactivating, death-inducing and dominant-negative activities. Mol. Cell. 1998;(2):365-381.
Mahanty SK, Wang YM, Farley FW, and Elion EA. Nuclear Shuttling of yeast scaffold Ste5 is required for its recruitment to the plasma membrane and activation of the mating MAPK cascade. Cell. 1999;98:501-513.
