Dr. Daniel Simon, MD, FACC, FAHA, FSCAI
Herman K Hellerstein Professor of Medicine
Case Western Reserve University School of Medicine
Chief of Cardiovascular Medicine, University Hospitals- Case Medical Center
Phone: 216-368-1145
Fax: 216-368-0556
E-mail: Daniel.Simon@UHhospitals.org
Research Summary:
Dr. Simon is the Chief of Cardiovascular Medicine, University Hospitals Case Medical Center and the Herman K Hellerstein Professor of Medicine. Dr Simon's research focuses on inflammation in vascular injury and repair, the role of Foxp1 in monocyte differentiation, and the role of Vitamin E in modulating integrin function in platelets and monocytes. He is also involved in numerous clinical trials at University Hospitals, Heart and Vascular Research Institute.
Original Publications: (last 5 years)
Danenberg HD, Szalai AJ, Swaminathan RV, Peng L, Chen Z, Seifert P, Fay WP, Simon DI, Edelman ER. Increased thrombosis after arterial injury in human c-reactive protein-transgenic mice. Circulation 2003;108:512-512.35.
Ehlers R, Ustinov V, Chen Z, Zhang X, Rao R, Luscinskas WF, Lopez J, Plow E, Simon DI. Targeting platelet-leukocyte interactions: Identification of the integrin Mac-1 binding site for the platelet counter-receptor glycoprotein Iba. J Exp Med. 2003; 198:1077-88.
Chen Z, Sakuma M, Zago AC, Zhang X, Shi C, Bucala R, Simon DI. Evidence for a role of macrophage migration inhibitory factor in vascular disease. Art Thromb Vasc Biol 2004; 24:1-8.
Shi C, Zhang X, Chen Z, Sulaiman K, Feinberg MW, Ballantyne CM, Jain MK, Simon DI. Integrin engagement regulates monocyte differentiation through the forkhead transcription factor Foxp1. J Clin Invest 2004;114:408-418.
Chen Z, Keaney JF, Jr, Chen Z, Schulz E, Sakuma M, Zhang X, Shi C, Hazen SL, Simon DI. Decreased neointimal formation in Nox2-deficient mice reveals a direct role for NADPH oxidase in vascular repair after angioplasty. PNAS USA 2004;101:13014-13019.
Sakata Y, Xiang F, Chen Z, Kiriyama Y, Kamei CN, Simon DI, Chin MT. The transcription factor CHF1/Hey2 regulates arterial neointimal formation by alteration of PDGF, HB-EGF and Rac1 signaling. Art Thromb Vasc Biol 2004;24:2069-2074.
Feinberg MW, Shimizu K, Lebedeva M, Haspel R, Takayama K, Chen Z, Frederick JP, Wang X-F, Simon DI, Mitchell RN, Jain MK. An essential role for Smad3 in regulating MCP-1 expression and vascular inflammation. Circ Res 2004;94:601-608.
SenBanerjee S, Lin Z, Atkins GB, Greif DM, Rao RM, Kumar A, Feinberg MW, Chen Z, Simon DI, Luscinskas FW, Michel TM, Gimbrone MA Jr, García-Cardeña G, Jain MK. Identification of KLF2 as a novel transcriptional regulator of endothelial pro-inflammatory activation. J Exp Med 2004;199:1305-1315.
Chen Z, Sakuma M, Wang Y, Ustinov V, Lopez J, Andre P, Plow E, Simon DI. Leukocyte engagement of platelet GP Iba via the integrin Mac-1 is critical for the biological response to vascular injury. Circulation 2005; 112: 2993-3000.
Healy A, Pickard M, Pradhan A, Wang Y, Chen Z, Croce K, Sakuma M, Shi C, Garasic J, Damokosh A, Dowie T, Poisson L, Lillie J, Libby P, Ridker P, Simon DI. Platelet expression profiling and clinical validation of myeloid-related protein-14 as a novel determinant of cardiovascular events. Circulation 2006; 113:2278-2284.
36. Shi C, Simon DI. Integrin signals, transcription factors, and monocyte differentiation. Trends in Cardiovascular Medicine 2006; 16:146-152.
Simon DI, Pompili V. A far-fetched benefit of inflammation. Circulation 2007;115:548-549.
Giugliano RP, Wiviott SD, Stone PH, Simon DI, Schweiger MJ, Bouchard A, Leesar MA, Goulder MA, Deitcher SR, McCabe CH, Braunwald E, on behalf of the ANTHEM-TIMI-32 Investigators. Recombinant nematode anticoagulant protein c2 (rNAPc2) in patients with non-ST-elevation acute coronary syndromes. J Amer Coll Cardiol 2007, in press.
