Can Shi, PhD
Phone: 216-368-2373
Fax: 216-368-2951
E-mail: can.shi@case.edu
Research Summary:
Dr. Shi studies the mechanism underlying cardiovascular injury. His research focus is on the regulation of gene expression by integrin engagement. These research efforts may provide insights into the development of therapeutic reagents to treat cardiovascular diseases that are associated with leukocyte and platelet interaction.
Original Publications: (last 5 years)
1. Letnansky K, Vetterlain M, Shi C. Inhibition of DNA synthesis and oncogene expression in animal and human tumor cells by the biological factor DIF. Anitcancer Res. 1991; 11:982-986.
2. Shi C, Letnansky K, Yao Z. In vitro transformation of LW13 rat liver epithelial cells. Cell Res. 1992;2:139-152.
3. Shi C, Hu YJ, Xu L, Wang P. Research on tumor-related genes inactivated in rat hepatoma cells. Acta Biologiae Experimentalis Sinica.1994; 27(4): 497-504.
4. Shi C, Wang P, Hu YJ, Xu L. Affinity chromatography dependent selection of genomic DNAs bound specifically to bacterial synthesized Myc/Myn proteins. Cell Res. 1995; 5(1):25-34.
5. Hu YJ, Xu L, Shi C, Liu JW. Research on tumor-related genes inactivated in rat hepatoma cells[2]: Morphologically reversed colonies on CBRH-7919 rat hepatoma cell cultures transfected by normal rat cDNA library. Acta Biologiae Experimentalis Sinica. 1996;29(3):287-295.
6. Chen Z, Woodburn KW, Shi C, Adelman DC, Rogers C, Simon DI. Photodynamic therapy with metafixin lutetium induces redox-sensitive apoptosis of vascular cells.Ateriosclerosis, Thorombosis, and Vascular Biology. 2001; 21:759-764.
7. Shi C, Zhang X, Chen Z, Robinson MK, Simon DI. Leukocyte integrin Mac-1 recruits toll/interleukin-1 receptor superfamily signaling intermediates to modulate NF-kappaB activity. Circulation Research. 2001; 89:859-865.
8. Shi C, Zhang X, Chen Z, Sulaiman K, Feinberg MW, Ballantyne CM, Jain MK, Simon DI. Integrin engagement regulates monocyte differentiation through the forkhead transcription factor Foxp1. J Clin Invest. 2004 Aug; 114(3):408-18.
9. Chen Z, Keaney JF Jr, Schulz E, Levison B, Shan L, Sakuma M, Zhang X, Shi C, Hazen SL, Simon DI. Decreased neointimal formation in Nox2-deficient mice reveals a direct role for NADPH oxidase in the response to arterial injury. Proc Natl Acad Sci U S A. 2004 Aug 31; 101(35): 13014-9.
10. Wang Y, Sakuma M, Chen Z, Ustinov V, Shi C, Croce K, Zago AC, Lopez J, Andre P, Plow E, Simon DI. Leukocyte engagement of platelet glycoprotein Iba via the integrin Mac 1 is critical for the biological response to vascular injury. Circulation. 2005 Nov 8; 112(19):2993-3000.
11. Healy AM, Pickard MD, Pradhan AD, Wang Y, Chen Z, Croce K, Sakuma M, Shi C, Zago AC, Garasic J, Damokosh AI, Dowie TL, Poisson L, Lillie J, Libby P, Ridker PM, Simon DI. Platelet expression profiling and clinical validation of myeloid-related protein-14 as a novel determinant of cardiovascular events. Circulation. 2006 May 16; 113(19):2278-84.
12. Shi C, Simon DI. Integrin signals, transcription factors and monocyte differentiation. Trends in Cardiovascular Medicine. 2006 Jul; 16(5):146-52.
