Aaron Proweller, MD, PhD
Phone: 216-368-0131
Fax: 216-368-0556
E-mail: aaron.proweller@case.edu
Research Summary:
Dr. Proweller is an Assistant Professor of Medicine in the Case Cardiovascular Research Institute at Case Western Reserve University and a faculty member in the Cardiovascular Division at University Hospitals-Case Medical Center. Dr. Proweller’s laboratory focuses on the molecular pathways regulating vascular development and morphogenesis including the role of Notch signaling in patterning and maturation of the arterial vasculature. The long-term goal in the laboratory is to define the molecular mechanisms in smooth muscle cells that underlie proper vascular formation and maturation and to determine how cellular derangements from Notch dysfunction are linked to adult vascular disease.
Original Publications: (last 5 years)
Proweller, A., Pear, W. S., and Parmacek, M. S. Notch signaling represses myocardin-induced smooth muscle cell differentiation. J Biol Chem 2005;280: 8994-9004.
Proweller, A., Tu, L., Lepore, J. J., Cheng, L., Lu, M. M., Seykora, J., Millar, S. E., Pear, W. S., and Parmacek, M. S. Impaired notch signaling promotes de novo squamous cell carcinoma formation. Cancer Res 2006;66: 7438-7444.
High, F. A., Zhang, M., Proweller, A., Tu, L., Parmacek, M. S., Pear, W. S., and Epstein, J. A. An essential role for Notch in neural crest during cardiovascular development and smooth muscle differentiation. J Clin Invest 2007: 117: 353-363.
Proweller, A., Wright, A. C., Horng, D., Cheng, L., Lu, M. M., Lepore, J. J., Pear, W. S., and Parmacek, M. S. Notch signaling in vascular smooth muscle cells is required to pattern the cerebral vasculature. Proc Natl Acad Sci U S A 2007;104:16275-16280.
Huang, J., Cheng, L., Li, J., Chen, M., Zhou, D., Lu, M. M., Proweller, A., Epstein, J. A., and Parmacek, M. S. Myocardin regulates expression of contractile genes in smooth muscle cells and is required for closure of the ductus arteriosus in mice. J Clin Invest 2008;118: 515-525.
