Zhiyong Lin, PhD
Phone: 216-368-0767
Fax: 216-368-0556
E-mail: zhiyong.lin@case.edu
Research Summary:
Dr Zhiyong Lin is an Assistant Professor at Case Western Reserve University School of Medicine. His research is primarily focused at exploring the novel link between KLF2 and PPARalpha in the context of endothelial gene expression and function.
Original Publications: (last 5 years)
Dong KW, Chi TF, Juan YW, Chen CW, Lin Z, Xiang XQ, Mahony M, Gibbons W, Oehninger S. Characterization of the biological activities of recombinant human zona pellucida protein 3 expressed in human ovarian teratocarcinoma (PA-1) cells. Am. J. Obstet. & Gynecol., 2001,184, 835-844.
Lin Z, Wu WL, Chen HQ. Effect of carbon and nitrogen sources on the production of exopolysaccharide by Derxia peritricha sp.nov. Journal of Fujian Agricultural University, 2001, 30(2): 217-222.
Lin Z, Chen HQ, Wu WL. Study on the appropriate conditions for the production of exopolysaccharide by Derxia peritricha sp.nov. Journal of Fujian Agricultual University, 2002, 31(1): 113-116.
Schuffner A., Bastiaan HS, Duran H, Lin Z, Morshedi M, Franken D, Oehninger S. Zona pellucida-induced acrosome reaction in the human: dependency on activation of pertussis toxin-sensitive Gi protein and calcium influx, and priming effect of progesterone and follicular fluid. Molecular Human Reproduction, 2002, 8(8): 722-727.
Lin Z#, SenBanerjee S, Atkins GB, Greif DM, Rao RM, Kumar A, Feinberg MW, Chen Z, Simon DI, Luscinscas FW, Michel TM, Gimbrone MA Jr., Garcia-Cardena G, Jain MK. KLF2 is a novel transcriptional regulator of endothelial proinflammatory activation. J. Exp. Med. 2004, 199(10): 1305-15
# Co-First author
Kumar A, Lin Z, SenBanerjee S, Jain MK. TNFa mediated reduction of KLF2 is due to inhibition of MEF2 by NF-kB and Histone Deacetylases. Mol. Cell Biol. 2005, 25(14): 5893-903.
SenBanerjee S, Mir S, Lin Z, Hamik A, Atkins GB, Kumar A, Das H, Jain MK. KLF2 as a novel mediator of statin effects in endothelial cells. Circulation 2005, 112(5):720-6
Bhattacharya R, SenBanerjee S, Lin Z, Mir S, Hamik A, Wang P, Mukhopadhyay D, Jain MK. Inhibition of VPF/VEGF-mediated angiogenesis by the Kruppel-like factor KLF2. J. Biol. Chem. 2005, 280(32): 28848-51
Lin Z, Kumar A, Sen-Banerjee S, Staniszewski K, Parmar K, Vaughan D, Gimbrone MA Jr., Balasubramanian V, Garcia-Cardena G, Jain MK. Kruppel-like Factor 2 (KLF2) Regulates Endothelial Thrombotic Function. Circ. Res. 2005, 96(5): e48-57
Parmar KM, Larman HB, Dai G, Zhang Y, Wang ET, Moorthi SN, Kratz JR, Lin Z, Jain M, Gimbrone MA Jr., García-Cardeña G. Integration of Flow-Dependent Endothelial Phenotype by KLF2. J. Clin. Invest. 2006, 116(1):49-58
Lin Z, Patino WD, Hwang PM, Feinberg MW, Majumder PK, Jain MK. The Kruppel-like Factor 2 (KLF2) regulates proinflammatory activation of monocytes. Proc. Natl. Acad. Sci. 2006, 103(17): 6653-6658
Lin Z, Hamik A, Jain R, Kumar A, Jain MK. Kruppel-like factor 2 inhibits Protease Activated Receptor-1 expression and thrombin-mediated endothelial activation. Arterioscler Thromb Vasc Biol. 2006, 26(5):1185-9
Fisch S, Gray S, Wang B, Cui L, Kumar A, Lin Z, SenBanerjee S, Das H, Petersen CA, Mende U, Burleigh BA, Liao R, Jain MK. The kruppel-like factor KLF15 is a novel regulator of cardiomyocyte hypertrophy. PNAS 2006 (submitted)
