Dr. Mukesh Jain, MD, FAHA
Ellery Sedgwick Jr. Chair and Distinguished Scientist
University Hospitals Case Medical Center
Director, Case Cardiovascular Research Institute
Phone: 216-368-3607
Fax: 216-368-0556
E-mail mukesh.jain2@case.edu
Research Summary:
Dr. Jain is Director of the Case Cardiovascular Research Institute at Case Western Reserve University and the Ellery Sedgwick Jr. Chair & Distinguished Scientist University Hospitals-Case Medical Center. Dr. Jain’s research focuses on transcriptional mechanisms governing cellular differentiation and function. His laboratory efforts have highlighted the importance of a family of factors termed Kruppel-like factors that regulate critical aspects of heart, blood vessel, and immune cell biology. These research efforts have spawned novel areas of investigation with therapeutic implications for disease conditions such as arteriosclerosis, heart failure, metabolism and regenerative medicine.
Original Publications: (last 5 years)
Sibinga NES, Feinberg MW, Yang H, Werner F, Jain MK. Macrophage restricted and interferon inducible expression of the allograft inflammatory factor-1 gene is mediated through Pu.1. Journal of Biological Chemistry 2002; 277(18):16202-10.
Watanabe M, Layne M, Gray S, Lee ME, Jain MK. Regulation of smooth muscle cell differentiation by AT-rich interacting domain transcription factor Mrf2a and Mrf2b. Circulation Research 2002; 91(5):382-9.
Gray S, Feinberg MW, Hull S, Kuo CT, Watanabe M, SenBanerjee S, Jain MK. The Kruppel-like Factor KLF15 regulates the insulin-sensitive glucose transporter GLUT4. Journal of Biological Chemistry 2002; 277(37):34322-8.
Sen-Banerjee S, Feinberg MW, Watanabe M, Gray S, Haspel R, Denkinger DK, Kawahara R, Hauner H, Jain MK. The Kruppel-like Factor KLF2 inhibits PPARg and adipogenesis. Journal of Biological Chemistry 2003; 278(4):2581-4.
Feinberg MW, Shimizu K, Lebedeva M, Haspel R, Takayama K, Chen Z, Frederick JP, Wang XF, Simon DI, Libby P, Mitchell RN, Jain MK. An essential role for Smad3 in regulating MCP-1 expression and vascular inflammation. Circulation Research 2004; 94(5): 601-608.
Feinberg MW, Watanabe M, Lebedeva MA, Depina AS, Hanai J, Mammoto T, Frederick JP, Wang XF, Sukhatme VP, Jain MK. Transforming growth factor beta-1 inhibition of vascular smooth muscle cell activation is mediated via Smad3. Journal of Biological Chemistry 2004: 279(16): 16388-16393.
SenBanerjee S, Lin Z, Atkins GB, Grief DM, Rao RM, Kumar A, Feinberg MW, Chen Z, Simon DI, Luscinskas FW, Michel TM, Gimbrone MA, Garcia-Cardena G, Jain MK. KLF2 is a novel transcriptional regulator of endothelial proinflammatory activation. Journal of Experimental Medicine 2004: 199(10):1305-1315.
Otteson DC, Liu Y, Lai H, Wang CW, Gray S, Jain MK, Zack DJ. KLF15, a zinc-finger transcriptional regulator, is a repressor of the rhodopsin and interphotoreceptor retinoid binding protein promoters. Invest. Opthhal & Visual Science, 2004; 45(8):2522-30.
Shi C, Zhang, X, Chen Z, Sulaiman K, Feinberg MW, Ballantyne CM, Jain MK, Simon DI. Integrin Engagement Regulates Monocyte Differentiation through the Forkhead Transcription Factor Foxp1. Journal of Clinical Investigation 2004;114(3):408-18.
Lin Z, Kumar A, SenBanerjee S, Staniszewski K, Parmar K, Vaughan DE, Gimbrone MA, Balasubramanian V, Garcia-cardena G, Jain MK. The Kruppel-like factor (KLF2) regulates endothelial thrombotic function. Circulation Research, 2005; 96(5):e48-57.
Kumar A, Lin Z, SenBanerjee S, Jain MK. TNFa mediated reduction of KLF2 is due to inhibition of MEF2 by NF-kB and Histone Deacetylases. Molecular and Cellular Biol. 2005; 25(14): 5893-903.
SenBanerjee S, Mir S, Lin Z, Hamik A, Atkins GB, Das H, Banerjee P, Kumar A, Jain MK. KLF2 as a novel mediator of statin effects in endothelial cells. Circulation 2005; 112(5): 720-726.
Bhattacharya R, SenBanerjee S, Lin Z, Mir S, Hamik A, Wang P, Mukherjee P, Mukhopadhyay D, Jain MK. Inhibition of VPF/VEGF-mediated angiogenesis by the Kruppel-like Factor KLF2. J Biol Chem. 2005 Aug 12;280(32):28848-5.
Wang GJ, Sui XX, Simosa HF, Jain MK, Altieri DC, Conte MS. Regulation of vein graft hyperplasia by survivin, an inhibitor of apoptosis protein (IAP). ATVB, 2005; 25(10): 2081-2087.
Feinberg MW, Zhuoxiao Cao, Akm Khyrul Wara, Maria A. Lebedeva, Sucharita SenBanerjee, and Jain MK. Kruppel-like Factor 4 (KLF4) is a mediator of proinflammatory signaling in macrophages. J Biol Chem, 2005; 280(46): 38247-38258.
Kuo R, SenBanerjee S, Jain MK, Michel T. Differential regulation of vascular endothelial growth factor receptors revealed by RNA interference: interactions of VEGFR-1 and VEGFR-2 in endothelial cell signaling. Biochemistry,2005; 44(45): 15064-15073.
Parmar K, Larman HB, Dai G, Zhang Y, Wang ET, Moorthi SN, Kratz JR, Lin Z, Jain MK, Gimbrone MA, Garcia-Cardena G. Integration of flow-dependent endothelial phenotype by KLF2. Journal of Clinical Investigation,2006; 116(1): 49-58.
Lin Z, Hamik A, Jain R, Kumar A, Jain MK. Kruppel-like Factor 2 inhibits Protease
Activated Receptor-1 expression and thrombin mediated endothelial activation. ATVB, 2006; 26(5): 1185-1189.
Das H, Kumar A, Lin Z, Patino W, Hwang P, Feinberg MW, Majumder PK, Jain MK. The
Kruppel-llike Factor 2 regulates proinflammatory activation of monocytes. PNAS, 2006; 103(17): 6653-6658.
Methe H, Balcells M, Alegret MD, Santacana M, Molins B, Hamik A, Jain MK,
Edelman ER. Vascular bed origin dictates flow pattern regulation of endothelial adhesion molecule expression. Am. J Physiol. Heart Circ Physiol., 2006, in press.
Gray S, Wang B, Orihuela Y, Hong EG, Fisch S, Haldar S, Cline GW, Kin JK, Peroni
OD, Kahn B, Jain MK. Regulation of gluconeogenesis by Kruppel-like factor 15
(KLF15). Cell Metabolism, 2007 Apr;5(4):305-12.
Hamik A, LinZ, Kumar A, Balcells M, Sinha S, Katz J, Feinberg MW, Gerszten R,
Edelman ER, and Jain MK. Kruppel-like factor 4 regulates endothelial inflammation.
Journal of Biological Chemistry, 2007 May 4;282(18):13769-79
Fisch S, Gray S, Heymans S, Haldar S, Wang B, Pfister O, Cui L, Kumar A, Lin Z,
Senbanerjee S, Das H, Petersen CA, Mende U, Burleigh BA, Zhu Y, Pinto Y, Liao R,
Jain MK. Kruppel-like factor 15 is a novel regulator of cardiomyocyte hypertrophy.
Proceedings of the National Academy of Sciences, 2007 Apr 24;104(17):7074-9.
Feinberg MW, Wara AK, Cao Z, Lebedeva M, Rosenbauer F, Iwasaki H, Hirai H, Haspel R, Gray S, Akashi K, Segre J, Kaestner K, Tenen DG, Jain MK. The Kruppel-like Factor KLF4 is a critical regulator of monocyte differentiation. EMBO J, 2007 in press.
