Anne Hamik, MD, PhD
Phone: 216-368-2005
Fax: 216-368-0556
E-mail: anne.hamik@case.edu
Research Summary:
Dr Anne Hamik is an Assistant Professor at Case Western Reserve University School of Medicine. Dr Hamik’s main area of research is the control of basic cell functions that regulate the inflammatory and pro-thrombotic state of blood vessels in the heart and elsewhere in the vascular tree. In particular, she studies the function of an endothelial cell transcription factor, KLF4, under homeostatic states such as laminar flow, and in pathological conditions such as hypoxia and inflammation.
Original Publications: (last 5 years)
Sen-Banerjee S, Mir S, Lin Z, Hamik A, Atkins GB, Das H, Banerjee P, Kumar A,
Jain MK: Kruppel-like factor 2 as a novel mediator of statin effects in endothelial cells. Circulation, 2:720-726, 2005.
Battacharya R, Senbanerjee, S, Lin Z, Mir S, Hamik A, Wang P, Mukherjee P,
Mukhopadhyay D, Jain MK: Inhibition of vascular permeability factor/vascular
endothelial growth factor-mediated angiogenesis by the Kruppel-like factor KLF2.
Journal of Biological Chemistry, 280:28848-28851, 2005.
Lin Z, Hamik A, Jain R, Kumar A, Jain MK: Kruppel-Like Factor 2 Inhibits Protease
Activated Receptor-1 Expression and Thrombin-Mediated Endothelial Activation.
Arteriosclerosis, Thrombosis, and Vascular Biology, 26(5): 1185-1189, 2006.
Methe H, Balcells M, del Carmen Alegret M, Santacana M, Molins B, Hamik A, Jain
MK, Edelman ER: Vascular bed origin dictates flow pattern regulation of endothelial
adhesion molecule expression. Am J Physiol Heart Circ Physiol, Epub Jan 2007.
Hamik A, Lin Z, Kumar A, Balcells M, Sinha S, Katz J, Feinberg M, Gerzsten RE,
Edelman, ER, Jain MJ: Kruppel-like factor 4 regulates endothelial inflammation.
Journal of Biological Chemistry, Epub March 5, 2007.
