Ruben Stepanyan, Ph.D.

  • Assistant Professor
  • Otolaryngology - Head and Neck Surgery
  • Case Western Reserve University School of Medicine





Biophysics - Armenian NAS Biophysics Center

Postdoctoral Training
University of Kentucky

Ruben Stepanyan is currently an Assistant Professor in the Department of Otolaryngology - Head and Neck Surgery.  After graduating from the department of Radiophysics at Yerevan State University he was accepted into the Armenian NAS Biophysics Center graduate program.  Upon graduation he undertook his postdoctoral training in the Department of Physiology, University of Kentucky, where he began his studies on mechanosensitivity of the sensory cells of the inner ear, the hair cells.  Hair cells are receptor cells, which are sensitive to sounds or accelerations.  The senses of hearing and balance depend on hair cells.  Auditory hair cells do not regenerate in mammals; their disappearance after exposure to noise, ototoxic drugs, or due to aging is associated with a permanent loss of hearing.  Understanding how these cells function will better enable us to develop plans and strategies for preventing or alleviating hearing loss. 


Indzhykulian AA, Stераnyаn R, Nelina A, Spinelli KJ, Ahmed ZM, Belyantseva IA, Friedman TB, Gillespie PG, Frolenkov GI.  Molecular remodeling of tip links underlies mechanosensory regeneration in auditory hair cells.  PLOS Biology. 2013. 11(6):e1001583.

Szarama KB, Stepanyan R, Petralia RS, Gavara N, Frolenkov GI, Kelley MW, Chadwick RS.  Fibroblast Growth Factor Receptor 3 regulates microtubule formation and cell surface mechanical properties in the developing organ of Corti.  BioArchitecture.  2012. 2(6):214-9.

Stераnyаn R, Indzhykulian AA, Vélez-Ortega AC, Boger ET, Steyger PS, Friedman TB, Frolenkov GI.  TRPA1-mediated accumulation of aminoglycosides in mouse cochlear outer hair cells.  J Assoc Res Otolaryngol.  2011. 12(6):729-40.

Kitajiri S, Sakamoto T, Belyantseva IA, Goodyear RJ, Stераnyаn R, Fujiwara I, Bird JE, Riazuddin S, Riazuddin S, Ahmed ZM, Hinshaw JE, Sellers J, Bartles JR, Hammer JA 3rd, Richardson GP, Griffith AJ, Frolenkov GI, Friedman TB.  Actin-bundling protein TRIOBP forms resilient rootlets of hair cell stereocilia essential for hearing.  Cell.  2010.  141(5):786-98.

Belyantseva IA, Perrin BJ, Snnemann K, Zhu M, Stераnyаn R, McGee JA, Frolenkov GI, Walsh E, Friderici KH, Friedman TB, Ervasti JM.  Gamma-actin is required for cytoskeletal maintenance but not development.  Proc Natl Acad Sci U S A.  2009.  106(24):9703-8.

Stераnyаn R, Frolenkov GI.  Fast adaptation and Ca2+-sensitivity of the mechanotransducer require myosin-XVa in inner but not outer cochlear hair cells.  Journal of Neuroscience.  2009.  29(13):4023-34.

Novak P, Li C, Shevchuk AI, Stераnyаn R, Caldwell M, Hughes S, Smart TG, Gorelik J, Ostanin VP, Lab MJ, Moss GW, Frolenkov GI, Klenerman D, Korchev YE. Nanoscale live-cell imaging using hopping probe ion conductance microscopy.  Nature Methods.  2009.  6(4):279-81.

Stераnyаn R, Belyantseva IA, Griffith AJ, Friedman TB, Frolenkov GI.  Auditory mechanotransduction in the absence of functional myosin-XVa.  Journal of Physiology (London).  2006.  576(3):801-8.